node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FolB | FolP | HMPREF3186_01076 | HMPREF3186_01022 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.995 |
FolB | KXB59572.1 | HMPREF3186_01076 | HMPREF3186_01077 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | KEGG: cst:CLOST_1758 5.8e-30 folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950; Psort location: Cytoplasmic, score: 7.50. | 0.998 |
FolB | folE | HMPREF3186_01076 | HMPREF3186_00999 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | KEGG: sif:Sinf_1066 3.7e-51 folE; GTP cyclohydrolase I K01495. | 0.907 |
FolB | ftsH | HMPREF3186_01076 | HMPREF3186_01515 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | ATP-dependent metallopeptidase HflB; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.481 |
FolB | ribA | HMPREF3186_01076 | HMPREF3186_00294 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | 0.451 |
FolP | FolB | HMPREF3186_01022 | HMPREF3186_01076 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.995 |
FolP | KXB59572.1 | HMPREF3186_01022 | HMPREF3186_01077 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | KEGG: cst:CLOST_1758 5.8e-30 folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950; Psort location: Cytoplasmic, score: 7.50. | 0.997 |
FolP | folE | HMPREF3186_01022 | HMPREF3186_00999 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | KEGG: sif:Sinf_1066 3.7e-51 folE; GTP cyclohydrolase I K01495. | 0.965 |
FolP | ftsH | HMPREF3186_01022 | HMPREF3186_01515 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | ATP-dependent metallopeptidase HflB; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.400 |
FolP | ribA | HMPREF3186_01022 | HMPREF3186_00294 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | 0.524 |
KXB59572.1 | FolB | HMPREF3186_01077 | HMPREF3186_01076 | KEGG: cst:CLOST_1758 5.8e-30 folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950; Psort location: Cytoplasmic, score: 7.50. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.998 |
KXB59572.1 | FolP | HMPREF3186_01077 | HMPREF3186_01022 | KEGG: cst:CLOST_1758 5.8e-30 folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950; Psort location: Cytoplasmic, score: 7.50. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.997 |
KXB59572.1 | Pyk_1 | HMPREF3186_01077 | HMPREF3186_01079 | KEGG: cst:CLOST_1758 5.8e-30 folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950; Psort location: Cytoplasmic, score: 7.50. | Pyruvate kinase, barrel domain protein; KEGG: clc:Calla_0654 2.8e-64 pyruvate kinase; K00873 pyruvate kinase; Psort location: Cytoplasmic, score: 7.50. | 0.475 |
KXB59572.1 | folE | HMPREF3186_01077 | HMPREF3186_00999 | KEGG: cst:CLOST_1758 5.8e-30 folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950; Psort location: Cytoplasmic, score: 7.50. | KEGG: sif:Sinf_1066 3.7e-51 folE; GTP cyclohydrolase I K01495. | 0.990 |
KXB59572.1 | ribA | HMPREF3186_01077 | HMPREF3186_00294 | KEGG: cst:CLOST_1758 5.8e-30 folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950; Psort location: Cytoplasmic, score: 7.50. | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | 0.625 |
NrdD | Pyk_1 | HMPREF3186_01595 | HMPREF3186_01079 | KEGG: efi:OG1RF_12115 1.4e-294 nrdD; anaerobic ribonucleoside-triphosphate reductase large subunit K00527; Psort location: Cytoplasmic, score: 7.50. | Pyruvate kinase, barrel domain protein; KEGG: clc:Calla_0654 2.8e-64 pyruvate kinase; K00873 pyruvate kinase; Psort location: Cytoplasmic, score: 7.50. | 0.900 |
NrdD | Pyk_2 | HMPREF3186_01595 | HMPREF3186_01365 | KEGG: efi:OG1RF_12115 1.4e-294 nrdD; anaerobic ribonucleoside-triphosphate reductase large subunit K00527; Psort location: Cytoplasmic, score: 7.50. | Pyruvate kinase; KEGG: afl:Aflv_0500 2.0e-153 pyruvate kinase; K00873 pyruvate kinase; Psort location: Cytoplasmic, score: 7.50. | 0.900 |
NrdD | Pyk_3 | HMPREF3186_01595 | HMPREF3186_01504 | KEGG: efi:OG1RF_12115 1.4e-294 nrdD; anaerobic ribonucleoside-triphosphate reductase large subunit K00527; Psort location: Cytoplasmic, score: 7.50. | Pyruvate kinase, barrel domain protein; KEGG: chd:Calhy_1460 9.2e-68 pyruvate kinase; K00873 pyruvate kinase; Psort location: Cytoplasmic, score: 7.50. | 0.900 |
NrdD | RelA_2 | HMPREF3186_01595 | HMPREF3186_00510 | KEGG: efi:OG1RF_12115 1.4e-294 nrdD; anaerobic ribonucleoside-triphosphate reductase large subunit K00527; Psort location: Cytoplasmic, score: 7.50. | GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.900 |
NrdD | folE | HMPREF3186_01595 | HMPREF3186_00999 | KEGG: efi:OG1RF_12115 1.4e-294 nrdD; anaerobic ribonucleoside-triphosphate reductase large subunit K00527; Psort location: Cytoplasmic, score: 7.50. | KEGG: sif:Sinf_1066 3.7e-51 folE; GTP cyclohydrolase I K01495. | 0.801 |