| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CadA_1 | CadA_2 | HMPREF3186_01226 | HMPREF3186_01225 | KEGG: sgy:Sgly_0023 2.1e-245 ATPase P; K01534 Cd2+/Zn2+-exporting ATPase; Psort location: CytoplasmicMembrane, score: 10.00. | Heavy metal-associated domain protein; KEGG: fnu:FN0259 1.5e-15 zinc-transporting ATPase; Psort location: Cytoplasmic, score: 7.50. | 0.896 |
| CadA_1 | CopA_2 | HMPREF3186_01226 | HMPREF3186_01043 | KEGG: sgy:Sgly_0023 2.1e-245 ATPase P; K01534 Cd2+/Zn2+-exporting ATPase; Psort location: CytoplasmicMembrane, score: 10.00. | Copper-exporting ATPase; KEGG: crn:CAR_c19150 2.3e-255 copA; copper transporter ATPase; K01533 Cu2+-exporting ATPase; Psort location: CytoplasmicMembrane, score: 10.00. | 0.676 |
| CadA_1 | KXB59649.1 | HMPREF3186_01226 | HMPREF3186_01044 | KEGG: sgy:Sgly_0023 2.1e-245 ATPase P; K01534 Cd2+/Zn2+-exporting ATPase; Psort location: CytoplasmicMembrane, score: 10.00. | Heavy metal-associated domain protein; KEGG: sif:Sinf_0238 3.1e-08 Copper chaperone. | 0.718 |
| CadA_1 | merA | HMPREF3186_01226 | HMPREF3186_00778 | KEGG: sgy:Sgly_0023 2.1e-245 ATPase P; K01534 Cd2+/Zn2+-exporting ATPase; Psort location: CytoplasmicMembrane, score: 10.00. | mercury(II) reductase; Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0). Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.661 |
| CadA_2 | CadA_1 | HMPREF3186_01225 | HMPREF3186_01226 | Heavy metal-associated domain protein; KEGG: fnu:FN0259 1.5e-15 zinc-transporting ATPase; Psort location: Cytoplasmic, score: 7.50. | KEGG: sgy:Sgly_0023 2.1e-245 ATPase P; K01534 Cd2+/Zn2+-exporting ATPase; Psort location: CytoplasmicMembrane, score: 10.00. | 0.896 |
| CadA_2 | CopA_2 | HMPREF3186_01225 | HMPREF3186_01043 | Heavy metal-associated domain protein; KEGG: fnu:FN0259 1.5e-15 zinc-transporting ATPase; Psort location: Cytoplasmic, score: 7.50. | Copper-exporting ATPase; KEGG: crn:CAR_c19150 2.3e-255 copA; copper transporter ATPase; K01533 Cu2+-exporting ATPase; Psort location: CytoplasmicMembrane, score: 10.00. | 0.595 |
| CadA_2 | KXB59649.1 | HMPREF3186_01225 | HMPREF3186_01044 | Heavy metal-associated domain protein; KEGG: fnu:FN0259 1.5e-15 zinc-transporting ATPase; Psort location: Cytoplasmic, score: 7.50. | Heavy metal-associated domain protein; KEGG: sif:Sinf_0238 3.1e-08 Copper chaperone. | 0.595 |
| CadA_2 | merA | HMPREF3186_01225 | HMPREF3186_00778 | Heavy metal-associated domain protein; KEGG: fnu:FN0259 1.5e-15 zinc-transporting ATPase; Psort location: Cytoplasmic, score: 7.50. | mercury(II) reductase; Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0). Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.661 |
| CopA_1 | CopA_2 | HMPREF3186_01525 | HMPREF3186_01043 | KEGG: spv:SPH_2289 3.1e-173 P-type ATPase-metal/cation transport; K01541 H+/K+-exchanging ATPase; Psort location: CytoplasmicMembrane, score: 8.78. | Copper-exporting ATPase; KEGG: crn:CAR_c19150 2.3e-255 copA; copper transporter ATPase; K01533 Cu2+-exporting ATPase; Psort location: CytoplasmicMembrane, score: 10.00. | 0.711 |
| CopA_1 | KXB59649.1 | HMPREF3186_01525 | HMPREF3186_01044 | KEGG: spv:SPH_2289 3.1e-173 P-type ATPase-metal/cation transport; K01541 H+/K+-exchanging ATPase; Psort location: CytoplasmicMembrane, score: 8.78. | Heavy metal-associated domain protein; KEGG: sif:Sinf_0238 3.1e-08 Copper chaperone. | 0.718 |
| CopA_1 | merA | HMPREF3186_01525 | HMPREF3186_00778 | KEGG: spv:SPH_2289 3.1e-173 P-type ATPase-metal/cation transport; K01541 H+/K+-exchanging ATPase; Psort location: CytoplasmicMembrane, score: 8.78. | mercury(II) reductase; Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0). Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.661 |
| CopA_2 | CadA_1 | HMPREF3186_01043 | HMPREF3186_01226 | Copper-exporting ATPase; KEGG: crn:CAR_c19150 2.3e-255 copA; copper transporter ATPase; K01533 Cu2+-exporting ATPase; Psort location: CytoplasmicMembrane, score: 10.00. | KEGG: sgy:Sgly_0023 2.1e-245 ATPase P; K01534 Cd2+/Zn2+-exporting ATPase; Psort location: CytoplasmicMembrane, score: 10.00. | 0.676 |
| CopA_2 | CadA_2 | HMPREF3186_01043 | HMPREF3186_01225 | Copper-exporting ATPase; KEGG: crn:CAR_c19150 2.3e-255 copA; copper transporter ATPase; K01533 Cu2+-exporting ATPase; Psort location: CytoplasmicMembrane, score: 10.00. | Heavy metal-associated domain protein; KEGG: fnu:FN0259 1.5e-15 zinc-transporting ATPase; Psort location: Cytoplasmic, score: 7.50. | 0.595 |
| CopA_2 | CopA_1 | HMPREF3186_01043 | HMPREF3186_01525 | Copper-exporting ATPase; KEGG: crn:CAR_c19150 2.3e-255 copA; copper transporter ATPase; K01533 Cu2+-exporting ATPase; Psort location: CytoplasmicMembrane, score: 10.00. | KEGG: spv:SPH_2289 3.1e-173 P-type ATPase-metal/cation transport; K01541 H+/K+-exchanging ATPase; Psort location: CytoplasmicMembrane, score: 8.78. | 0.711 |
| CopA_2 | CopY | HMPREF3186_01043 | HMPREF3186_01099 | Copper-exporting ATPase; KEGG: crn:CAR_c19150 2.3e-255 copA; copper transporter ATPase; K01533 Cu2+-exporting ATPase; Psort location: CytoplasmicMembrane, score: 10.00. | Copper transport repressor, CopY/TcrY family; KEGG: bcz:BCZK0993 2.8e-14 blaI; beta-lactamase K07737; Psort location: Cytoplasmic, score: 7.50. | 0.756 |
| CopA_2 | CsoR | HMPREF3186_01043 | HMPREF3186_00462 | Copper-exporting ATPase; KEGG: crn:CAR_c19150 2.3e-255 copA; copper transporter ATPase; K01533 Cu2+-exporting ATPase; Psort location: CytoplasmicMembrane, score: 10.00. | Hypothetical protein; Psort location: Cytoplasmic, score: 7.50. | 0.691 |
| CopA_2 | FieF | HMPREF3186_01043 | HMPREF3186_00164 | Copper-exporting ATPase; KEGG: crn:CAR_c19150 2.3e-255 copA; copper transporter ATPase; K01533 Cu2+-exporting ATPase; Psort location: CytoplasmicMembrane, score: 10.00. | Cation diffusion facilitator family transporter; KEGG: bqy:MUS_0639 6.8e-59 yeaB; cation efflux system protein (zinc/cadmium/cobalt); Psort location: CytoplasmicMembrane, score: 9.99; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. | 0.578 |
| CopA_2 | KXB59649.1 | HMPREF3186_01043 | HMPREF3186_01044 | Copper-exporting ATPase; KEGG: crn:CAR_c19150 2.3e-255 copA; copper transporter ATPase; K01533 Cu2+-exporting ATPase; Psort location: CytoplasmicMembrane, score: 10.00. | Heavy metal-associated domain protein; KEGG: sif:Sinf_0238 3.1e-08 Copper chaperone. | 0.898 |
| CopA_2 | KXB60316.1 | HMPREF3186_01043 | HMPREF3186_00813 | Copper-exporting ATPase; KEGG: crn:CAR_c19150 2.3e-255 copA; copper transporter ATPase; K01533 Cu2+-exporting ATPase; Psort location: CytoplasmicMembrane, score: 10.00. | Chloride transporter, ClC family; KEGG: cpr:CPR_1400 1.1e-83 chloride channel protein K01529; Psort location: CytoplasmicMembrane, score: 10.00. | 0.566 |
| CopA_2 | KXB61953.1 | HMPREF3186_01043 | HMPREF3186_00519 | Copper-exporting ATPase; KEGG: crn:CAR_c19150 2.3e-255 copA; copper transporter ATPase; K01533 Cu2+-exporting ATPase; Psort location: CytoplasmicMembrane, score: 10.00. | Putative cadmium, cobalt and zinc/H(+)-K(+) antiporter; KEGG: eci:UTI89_C0749 3.3e-43 zinc transporter ZitB K03295; Psort location: CytoplasmicMembrane, score: 10.00. | 0.590 |