STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ligADNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (663 aa)    
Predicted Functional Partners:
RsmB
Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
  
  
 0.943
PcrA_2
KEGG: sdt:SPSE_0837 2.4e-173 pcrA; ATP-dependent DNA helicase PcrA K03657; Psort location: Cytoplasmic, score: 9.95.
 
  
 0.940
RecJ
single-stranded-DNA-specific exonuclease RecJ; KEGG: sha:SH1285 1.8e-131 hypothetical protein; K07462 single-stranded-DNA-specific exonuclease; Psort location: Cytoplasmic, score: 7.50.
 
  
 0.859
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
   
 0.844
KXB59387.1
Hypothetical protein; Psort location: CytoplasmicMembrane, score: 9.55.
       0.773
leuS
leucine--tRNA ligase; KEGG: bcy:Bcer98_3415 0. leuS; leucyl-tRNA synthetase; K01869 leucyl-tRNA synthetase; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 
 
 0.706
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 
 0.690
TopB
KEGG: cbn:CbC4_2099 9.8e-186 DNA topoisomerase III; K03169 DNA topoisomerase III; Psort location: Cytoplasmic, score: 9.97.
   
 
 0.690
KXB59389.1
KEGG: chu:CHU_3640 3.0e-26 dsbC; protein-disulfide isomerase K07396; Psort location: Cytoplasmic, score: 7.50.
       0.607
KXB59381.1
Kinase domain protein; KEGG: gwc:GWCH70_1067 9.3e-110 serine/threonine protein kinase with PASTA sensor(s); K08884 serine/threonine protein kinase, bacterial; Psort location: CytoplasmicMembrane, score: 9.51.
  
  
 0.594
Your Current Organism:
Gemella haemolysans
NCBI taxonomy Id: 1379
Other names: ATCC 10379, CCUG 37985, CIP 101126, G. haemolysans, LMG 18984, LMG:18984, NCTC 12968, Neisseria haemolysans
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.