STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hprKHPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable car [...] (314 aa)    
Predicted Functional Partners:
lgt
Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family.
  
  
 0.898
PtsH
Phosphocarrier protein HPr; KEGG: suh:SAMSHR1132_09300 6.0e-28 phosphocarrier protein HPr K11189; Psort location: Cytoplasmic, score: 10.00.
 
 
 
 0.827
TrxB_2
KEGG: bcy:Bcer98_3701 3.4e-105 thioredoxin reductase; K00384 thioredoxin reductase (NADPH); Psort location: Cytoplasmic, score: 9.67.
     
 0.810
KXB58275.1
Hypothetical protein; KEGG: lki:LKI_08340 1.7e-07 HPr kinase/phosphorylase K08972; Psort location: CytoplasmicMembrane, score: 10.00.
     
 0.753
KXB57905.1
KEGG: bpf:BpOF4_13510 8.5e-45 phnA; alkylphosphonate utilization operon protein PhnA; K06193 phosphonoacetate hydrolase.
      0.747
uvrB
Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
    
 0.723
FruA
KEGG: aur:HMPREF9243_1309 1.3e-181 fruA_2; PTS system fructose-specific transporter subunit IIABC; K02768 PTS system, fructose-specific IIA component; K02769 PTS system, fructose-specific IIB component K02770; Psort location: CytoplasmicMembrane, score: 10.00.
  
  
 0.692
KXB59381.1
Kinase domain protein; KEGG: gwc:GWCH70_1067 9.3e-110 serine/threonine protein kinase with PASTA sensor(s); K08884 serine/threonine protein kinase, bacterial; Psort location: CytoplasmicMembrane, score: 9.51.
   
 
 0.642
ManX
Putative PTS system mannose-specific EIIAB component; KEGG: lba:Lebu_0457 2.4e-127 PTS system mannose/fructose/sorbose family transporter subunit IIA; K02793 PTS system, mannose-specific IIA component K02794; Psort location: Cytoplasmic, score: 9.97.
  
  
 0.596
KXB59539.1
2-oxoacid:acceptor oxidoreductase, alpha subunit; KEGG: sca:Sca_0932 9.3e-142 putative pyruvate flavodoxin/ferredoxin oxidoreductase; K00174 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Psort location: Cytoplasmic, score: 7.50.
   
   0.540
Your Current Organism:
Gemella haemolysans
NCBI taxonomy Id: 1379
Other names: ATCC 10379, CCUG 37985, CIP 101126, G. haemolysans, LMG 18984, LMG:18984, NCTC 12968, Neisseria haemolysans
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