| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KXB62153.1 | dnaJ | HMPREF3186_00474 | HMPREF3186_00211 | RNA methyltransferase, TrmH family, group 3; KEGG: mcl:MCCL_1876 5.3e-68 hypothetical protein; K03218 23S rRNA (guanosine2251-2'-O)-methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.594 |
| KXB62153.1 | engB | HMPREF3186_00474 | HMPREF3186_01657 | RNA methyltransferase, TrmH family, group 3; KEGG: mcl:MCCL_1876 5.3e-68 hypothetical protein; K03218 23S rRNA (guanosine2251-2'-O)-methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Ribosome biogenesis GTP-binding protein YsxC; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. | 0.662 |
| KXB62153.1 | mnmE | HMPREF3186_00474 | HMPREF3186_00025 | RNA methyltransferase, TrmH family, group 3; KEGG: mcl:MCCL_1876 5.3e-68 hypothetical protein; K03218 23S rRNA (guanosine2251-2'-O)-methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 0.594 |
| KXB62153.1 | rplC | HMPREF3186_00474 | HMPREF3186_01770 | RNA methyltransferase, TrmH family, group 3; KEGG: mcl:MCCL_1876 5.3e-68 hypothetical protein; K03218 23S rRNA (guanosine2251-2'-O)-methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | 50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | 0.588 |
| KXB62153.1 | rplQ | HMPREF3186_00474 | HMPREF3186_01797 | RNA methyltransferase, TrmH family, group 3; KEGG: mcl:MCCL_1876 5.3e-68 hypothetical protein; K03218 23S rRNA (guanosine2251-2'-O)-methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Ribosomal protein L17; KEGG: apb:SAR116_2416 1.6e-20 50S ribosomal protein L17 K02879; Psort location: Cytoplasmic, score: 9.97. | 0.592 |
| KXB62153.1 | rplU | HMPREF3186_00474 | HMPREF3186_00900 | RNA methyltransferase, TrmH family, group 3; KEGG: mcl:MCCL_1876 5.3e-68 hypothetical protein; K03218 23S rRNA (guanosine2251-2'-O)-methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. | 0.584 |
| KXB62153.1 | rplX | HMPREF3186_00474 | HMPREF3186_01781 | RNA methyltransferase, TrmH family, group 3; KEGG: mcl:MCCL_1876 5.3e-68 hypothetical protein; K03218 23S rRNA (guanosine2251-2'-O)-methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. | 0.591 |
| KXB62153.1 | rsfS | HMPREF3186_00474 | HMPREF3186_01095 | RNA methyltransferase, TrmH family, group 3; KEGG: mcl:MCCL_1876 5.3e-68 hypothetical protein; K03218 23S rRNA (guanosine2251-2'-O)-methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.582 |
| Lon1 | clpX | HMPREF3186_01656 | HMPREF3186_01655 | Endopeptidase La; KEGG: gte:GTCCBUS3UF5_29780 3.1e-171 ATP-dependent protease La; K01338 ATP-dependent Lon protease; Psort location: Cytoplasmic, score: 9.97. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.917 |
| Lon1 | dnaJ | HMPREF3186_01656 | HMPREF3186_00211 | Endopeptidase La; KEGG: gte:GTCCBUS3UF5_29780 3.1e-171 ATP-dependent protease La; K01338 ATP-dependent Lon protease; Psort location: Cytoplasmic, score: 9.97. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.680 |
| Lon1 | engB | HMPREF3186_01656 | HMPREF3186_01657 | Endopeptidase La; KEGG: gte:GTCCBUS3UF5_29780 3.1e-171 ATP-dependent protease La; K01338 ATP-dependent Lon protease; Psort location: Cytoplasmic, score: 9.97. | Ribosome biogenesis GTP-binding protein YsxC; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. | 0.805 |
| clpX | Lon1 | HMPREF3186_01655 | HMPREF3186_01656 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Endopeptidase La; KEGG: gte:GTCCBUS3UF5_29780 3.1e-171 ATP-dependent protease La; K01338 ATP-dependent Lon protease; Psort location: Cytoplasmic, score: 9.97. | 0.917 |
| clpX | engB | HMPREF3186_01655 | HMPREF3186_01657 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Ribosome biogenesis GTP-binding protein YsxC; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. | 0.733 |
| dnaJ | KXB62153.1 | HMPREF3186_00211 | HMPREF3186_00474 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | RNA methyltransferase, TrmH family, group 3; KEGG: mcl:MCCL_1876 5.3e-68 hypothetical protein; K03218 23S rRNA (guanosine2251-2'-O)-methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | 0.594 |
| dnaJ | Lon1 | HMPREF3186_00211 | HMPREF3186_01656 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Endopeptidase La; KEGG: gte:GTCCBUS3UF5_29780 3.1e-171 ATP-dependent protease La; K01338 ATP-dependent Lon protease; Psort location: Cytoplasmic, score: 9.97. | 0.680 |
| dnaJ | engB | HMPREF3186_00211 | HMPREF3186_01657 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Ribosome biogenesis GTP-binding protein YsxC; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. | 0.645 |
| dnaJ | mnmE | HMPREF3186_00211 | HMPREF3186_00025 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 0.716 |
| dnaJ | rplC | HMPREF3186_00211 | HMPREF3186_01770 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | 0.838 |
| dnaJ | rplQ | HMPREF3186_00211 | HMPREF3186_01797 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Ribosomal protein L17; KEGG: apb:SAR116_2416 1.6e-20 50S ribosomal protein L17 K02879; Psort location: Cytoplasmic, score: 9.97. | 0.849 |
| dnaJ | rplU | HMPREF3186_00211 | HMPREF3186_00900 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. | 0.653 |