| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GpsB | KXB57623.1 | HMPREF3186_01681 | HMPREF3186_01676 | Putative cell cycle protein GpsB; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. | Hypothetical protein; Psort location: Cytoplasmic, score: 7.50. | 0.458 |
| GpsB | KXB57625.1 | HMPREF3186_01681 | HMPREF3186_01678 | Putative cell cycle protein GpsB; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. | Hypothetical protein; Belongs to the UPF0473 family. | 0.436 |
| GpsB | RsmE | HMPREF3186_01681 | HMPREF3186_01680 | Putative cell cycle protein GpsB; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. | RNA methyltransferase, RsmE family; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | 0.795 |
| GpsB | YrrK | HMPREF3186_01681 | HMPREF3186_01677 | Putative cell cycle protein GpsB; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. | RNAse H domain protein, YqgF family; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. | 0.416 |
| GpsB | mltG | HMPREF3186_01681 | HMPREF3186_01679 | Putative cell cycle protein GpsB; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. | YceG family protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. | 0.711 |
| KXB57618.1 | KXB57621.1 | HMPREF3186_01671 | HMPREF3186_01674 | Dinuclear metal center protein, YbgI family; KEGG: hip:CGSHiEE_02770 2.4e-12 seryl-tRNA synthetase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.710 |
| KXB57618.1 | KXB57622.1 | HMPREF3186_01671 | HMPREF3186_01675 | Dinuclear metal center protein, YbgI family; KEGG: hip:CGSHiEE_02770 2.4e-12 seryl-tRNA synthetase. | EDD domain protein, DegV family; KEGG: mgf:MGF_3873 5.9e-21 DegV-like protein; Psort location: Cytoplasmic, score: 7.50. | 0.697 |
| KXB57618.1 | KXB57623.1 | HMPREF3186_01671 | HMPREF3186_01676 | Dinuclear metal center protein, YbgI family; KEGG: hip:CGSHiEE_02770 2.4e-12 seryl-tRNA synthetase. | Hypothetical protein; Psort location: Cytoplasmic, score: 7.50. | 0.661 |
| KXB57618.1 | KXB57625.1 | HMPREF3186_01671 | HMPREF3186_01678 | Dinuclear metal center protein, YbgI family; KEGG: hip:CGSHiEE_02770 2.4e-12 seryl-tRNA synthetase. | Hypothetical protein; Belongs to the UPF0473 family. | 0.588 |
| KXB57618.1 | MntR | HMPREF3186_01671 | HMPREF3186_01672 | Dinuclear metal center protein, YbgI family; KEGG: hip:CGSHiEE_02770 2.4e-12 seryl-tRNA synthetase. | Transcriptional regulator MntR; KEGG: tid:Thein_1867 0.0014 adenylosuccinate lyase; K01756 adenylosuccinate lyase; Psort location: Cytoplasmic, score: 7.50. | 0.740 |
| KXB57618.1 | YrrK | HMPREF3186_01671 | HMPREF3186_01677 | Dinuclear metal center protein, YbgI family; KEGG: hip:CGSHiEE_02770 2.4e-12 seryl-tRNA synthetase. | RNAse H domain protein, YqgF family; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. | 0.661 |
| KXB57618.1 | mltG | HMPREF3186_01671 | HMPREF3186_01679 | Dinuclear metal center protein, YbgI family; KEGG: hip:CGSHiEE_02770 2.4e-12 seryl-tRNA synthetase. | YceG family protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. | 0.628 |
| KXB57618.1 | thyA | HMPREF3186_01671 | HMPREF3186_01673 | Dinuclear metal center protein, YbgI family; KEGG: hip:CGSHiEE_02770 2.4e-12 seryl-tRNA synthetase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.728 |
| KXB57621.1 | KXB57618.1 | HMPREF3186_01674 | HMPREF3186_01671 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dinuclear metal center protein, YbgI family; KEGG: hip:CGSHiEE_02770 2.4e-12 seryl-tRNA synthetase. | 0.710 |
| KXB57621.1 | KXB57622.1 | HMPREF3186_01674 | HMPREF3186_01675 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | EDD domain protein, DegV family; KEGG: mgf:MGF_3873 5.9e-21 DegV-like protein; Psort location: Cytoplasmic, score: 7.50. | 0.796 |
| KXB57621.1 | KXB57623.1 | HMPREF3186_01674 | HMPREF3186_01676 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Hypothetical protein; Psort location: Cytoplasmic, score: 7.50. | 0.742 |
| KXB57621.1 | KXB57625.1 | HMPREF3186_01674 | HMPREF3186_01678 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Hypothetical protein; Belongs to the UPF0473 family. | 0.650 |
| KXB57621.1 | MntR | HMPREF3186_01674 | HMPREF3186_01672 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Transcriptional regulator MntR; KEGG: tid:Thein_1867 0.0014 adenylosuccinate lyase; K01756 adenylosuccinate lyase; Psort location: Cytoplasmic, score: 7.50. | 0.731 |
| KXB57621.1 | RsmE | HMPREF3186_01674 | HMPREF3186_01680 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | RNA methyltransferase, RsmE family; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | 0.402 |
| KXB57621.1 | YrrK | HMPREF3186_01674 | HMPREF3186_01677 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | RNAse H domain protein, YqgF family; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. | 0.742 |