EQB63701.1 protein (candidate division Zixibacteria bacterium RBG1)

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

EQB63701.1

Two component, sigma54 specific, transcriptional regulator, Fis family; RBG1_1_1280; RBG1_1280. (152 aa)

Predicted Functional Partners:

EQB62578.1

0.950

EQB62708.1

0.928

EQB63218.1

0.896

EQB62999.1

0.894

EQB62674.1

0.889

EQB63842.1

0.884

EQB63645.1

0.853

EQB63696.1

0.841

EQB63843.1

0.824

EQB62436.1

0.823

Your Current Organism:

candidate division Zixibacteria bacterium RBG1

NCBI taxonomy Id: 1379698
Other names: c. division Zixibacteria bacterium RBG-1, candidate division ZIXI bacterium RBG-1, candidate division Zixibacteria bacterium RBG-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EQB62436.1	EQB62578.1	RBG1_1C00001G0015	RBG1_1C00001G0157	Two-component sensor kinase; RBG1_1_15; RBG1_15.	Sensor protein; RBG1_1_157; RBG1_157.	0.794
EQB62436.1	EQB62674.1	RBG1_1C00001G0015	RBG1_1C00001G0253	Two-component sensor kinase; RBG1_1_15; RBG1_15.	Hypothetical protein; RBG1_1_253; RBG1_253.	0.802
EQB62436.1	EQB62708.1	RBG1_1C00001G0015	RBG1_1C00001G0287	Two-component sensor kinase; RBG1_1_15; RBG1_15.	Sensory box histidine kinase; RBG1_1_287; RBG1_287.	0.808
EQB62436.1	EQB62999.1	RBG1_1C00001G0015	RBG1_1C00001G0578	Two-component sensor kinase; RBG1_1_15; RBG1_15.	Hypothetical protein; RBG1_1_578; RBG1_578.	0.415
EQB62436.1	EQB63218.1	RBG1_1C00001G0015	RBG1_1C00001G0797	Two-component sensor kinase; RBG1_1_15; RBG1_15.	PAS sensor protein; RBG1_1_797; RBG1_797.	0.828
EQB62436.1	EQB63645.1	RBG1_1C00001G0015	RBG1_1C00001G1224	Two-component sensor kinase; RBG1_1_15; RBG1_15.	Hypothetical protein; RBG1_1_1224; RBG1_1224.	0.935
EQB62436.1	EQB63701.1	RBG1_1C00001G0015	RBG1_1C00001G1280	Two-component sensor kinase; RBG1_1_15; RBG1_15.	Two component, sigma54 specific, transcriptional regulator, Fis family; RBG1_1_1280; RBG1_1280.	0.823
EQB62436.1	EQB63842.1	RBG1_1C00001G0015	RBG1_1C00001G1421	Two-component sensor kinase; RBG1_1_15; RBG1_15.	GAF sensor hybrid histidine kinase; RBG1_1_1421; RBG1_1421.	0.839
EQB62436.1	EQB63843.1	RBG1_1C00001G0015	RBG1_1C00001G1422	Two-component sensor kinase; RBG1_1_15; RBG1_15.	Multi-sensor hybrid histidine kinase; RBG1_1_1422; RBG1_1422.	0.900
EQB62578.1	EQB62436.1	RBG1_1C00001G0157	RBG1_1C00001G0015	Sensor protein; RBG1_1_157; RBG1_157.	Two-component sensor kinase; RBG1_1_15; RBG1_15.	0.794
EQB62578.1	EQB62674.1	RBG1_1C00001G0157	RBG1_1C00001G0253	Sensor protein; RBG1_1_157; RBG1_157.	Hypothetical protein; RBG1_1_253; RBG1_253.	0.999
EQB62578.1	EQB62708.1	RBG1_1C00001G0157	RBG1_1C00001G0287	Sensor protein; RBG1_1_157; RBG1_157.	Sensory box histidine kinase; RBG1_1_287; RBG1_287.	0.999
EQB62578.1	EQB62999.1	RBG1_1C00001G0157	RBG1_1C00001G0578	Sensor protein; RBG1_1_157; RBG1_157.	Hypothetical protein; RBG1_1_578; RBG1_578.	0.866
EQB62578.1	EQB63218.1	RBG1_1C00001G0157	RBG1_1C00001G0797	Sensor protein; RBG1_1_157; RBG1_157.	PAS sensor protein; RBG1_1_797; RBG1_797.	0.999
EQB62578.1	EQB63645.1	RBG1_1C00001G0157	RBG1_1C00001G1224	Sensor protein; RBG1_1_157; RBG1_157.	Hypothetical protein; RBG1_1_1224; RBG1_1224.	0.999
EQB62578.1	EQB63696.1	RBG1_1C00001G0157	RBG1_1C00001G1275	Sensor protein; RBG1_1_157; RBG1_157.	Histidine kinase protein; RBG1_1_1275; RBG1_1275.	0.792
EQB62578.1	EQB63701.1	RBG1_1C00001G0157	RBG1_1C00001G1280	Sensor protein; RBG1_1_157; RBG1_157.	Two component, sigma54 specific, transcriptional regulator, Fis family; RBG1_1_1280; RBG1_1280.	0.950
EQB62578.1	EQB63842.1	RBG1_1C00001G0157	RBG1_1C00001G1421	Sensor protein; RBG1_1_157; RBG1_157.	GAF sensor hybrid histidine kinase; RBG1_1_1421; RBG1_1421.	0.999
EQB62578.1	EQB63843.1	RBG1_1C00001G0157	RBG1_1C00001G1422	Sensor protein; RBG1_1_157; RBG1_157.	Multi-sensor hybrid histidine kinase; RBG1_1_1422; RBG1_1422.	0.999
EQB62674.1	EQB62436.1	RBG1_1C00001G0253	RBG1_1C00001G0015	Hypothetical protein; RBG1_1_253; RBG1_253.	Two-component sensor kinase; RBG1_1_15; RBG1_15.	0.802

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Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.982

expected number of edges:

43

PPI enrichment p-value:

0.325

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

6 of 53

1.58

1.99

7.04e-06

GO:0050896

Response to stimulus

9 of 315

0.98

1.04

7.04e-06

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

6 of 61

1.52

1.88

8.42e-06

GO:0016772

Transferase activity, transferring phosphorus-containing groups

7 of 234

1.0

0.94

0.00017

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2982

PAS domain superfamily, and GAF domain

9 of 31

1.99

5.18

3.35e-14

CL:2985

PAS domain

7 of 20

2.07

4.67

1.24e-11

CL:2986

PAS fold-4, and Signal transduction histidine kinase, phosphotransfer (Hpt) domain

6 of 15

2.13

4.29

3.52e-10

CL:2991

PAS fold-4, and Histidine Phosphotransfer domain

3 of 10

2.0

1.83

0.00021

CL:2994

Mixed, incl. Phytochrome chromophore attachment domain, and CheB methylesterase

2 of 5

2.13

1.18

0.0060

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

9 of 346

0.94

1.0

3.51e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

6 of 70

1.46

1.83

5.91e-06

KW-0418

Kinase

6 of 120

1.23

1.29

6.27e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

8 of 53

1.71

3.2

7.79e-10

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

8 of 56

1.68

3.14

7.79e-10

IPR005467

Histidine kinase domain

8 of 58

1.67

3.09

7.79e-10

IPR035965

PAS domain superfamily

8 of 59

1.66

3.07

7.79e-10

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

8 of 67

1.6

2.91

8.84e-10

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

8 of 57

1.67

3.29

1.11e-10

SM00091

PAS domain

7 of 57

1.62

2.77

6.22e-09

SM00387

Histidine kinase-like ATPases

7 of 60

1.59

2.72

6.22e-09

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

6 of 43

1.67

2.69

5.21e-08

SM00448

cheY-homologous receiver domain

6 of 58

1.54

2.28

2.20e-07

(more ...)

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