node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ddlB | ftsA | SYMBAF_10145 | SYMBAF_10147 | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | 0.997 |
ddlB | ftsQ | SYMBAF_10145 | SYMBAF_10146 | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Membrane anchored protein involved in growth of wall at septum; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | 0.997 |
ddlB | ftsW | SYMBAF_10145 | SYMBAF_10142 | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Integral membrane protein involved in stabilizing FstZ ring during cell division; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | 0.995 |
ddlB | ftsZ | SYMBAF_10145 | SYMBAF_10148 | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | GTP-binding tubulin-like cell division protein (Cell division protein FtsZ); Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.985 |
ddlB | murC | SYMBAF_10145 | SYMBAF_10144 | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylmuramate:L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.999 |
ddlB | murE | SYMBAF_10145 | SYMBAF_10138 | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso- diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.998 |
ddlB | murF | SYMBAF_10145 | SYMBAF_10139 | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.999 |
ddlB | murG | SYMBAF_10145 | SYMBAF_10143 | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.997 |
ddlB | yjeP | SYMBAF_10145 | SYMBAF_180063 | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Putative mechanosensitive channel; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. | 0.955 |
ddlB | zipA | SYMBAF_10145 | SYMBAF_20313 | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Cell division protein involved in Z ring assembly; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. | 0.874 |
ftsA | ddlB | SYMBAF_10147 | SYMBAF_10145 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | 0.997 |
ftsA | ftsQ | SYMBAF_10147 | SYMBAF_10146 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Membrane anchored protein involved in growth of wall at septum; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | 0.999 |
ftsA | ftsW | SYMBAF_10147 | SYMBAF_10142 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Integral membrane protein involved in stabilizing FstZ ring during cell division; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | 0.996 |
ftsA | ftsZ | SYMBAF_10147 | SYMBAF_10148 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | GTP-binding tubulin-like cell division protein (Cell division protein FtsZ); Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.999 |
ftsA | murC | SYMBAF_10147 | SYMBAF_10144 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | UDP-N-acetylmuramate:L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.997 |
ftsA | murE | SYMBAF_10147 | SYMBAF_10138 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso- diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.991 |
ftsA | murF | SYMBAF_10147 | SYMBAF_10139 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.988 |
ftsA | murG | SYMBAF_10147 | SYMBAF_10143 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.992 |
ftsA | yjeP | SYMBAF_10147 | SYMBAF_180063 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Putative mechanosensitive channel; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. | 0.976 |
ftsA | zipA | SYMBAF_10147 | SYMBAF_20313 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Cell division protein involved in Z ring assembly; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. | 0.959 |