EST39104.1 protein (Streptomycetaceae bacterium MP11305)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

EST39104.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (430 aa)

Predicted Functional Partners:

EST37469.1

0.592

EST29048.1

0.564

EST22310.1

0.522

EST37547.1

0.508

EST37126.1

0.498

EST23088.1

0.474

EST35872.1

0.468

EST29049.1

0.468

EST39187.1

0.456

EST32534.1

0.455

Your Current Organism:

Streptomycetaceae bacterium MP11305

NCBI taxonomy Id: 1380770
Other names: S. bacterium MP113-05, Streptomycetaceae bacterium MP113-05

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EST22310.1	EST29049.1	N566_26690	N566_22505	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.607
EST22310.1	EST32534.1	N566_26690	N566_20035	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.660
EST22310.1	EST35872.1	N566_26690	N566_17145	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.611
EST22310.1	EST37469.1	N566_26690	N566_12885	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.764
EST22310.1	EST39104.1	N566_26690	N566_03875	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.522
EST23088.1	EST32534.1	N566_26080	N566_20035	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.413
EST23088.1	EST37126.1	N566_26080	N566_14710	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Regulatory protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.625
EST23088.1	EST39104.1	N566_26080	N566_03875	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.474
EST23088.1	EST39187.1	N566_26080	N566_03380	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.533
EST29048.1	EST29049.1	N566_22500	N566_22505	Cellulose-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.748
EST29048.1	EST35872.1	N566_22500	N566_17145	Cellulose-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.668
EST29048.1	EST37126.1	N566_22500	N566_14710	Cellulose-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Regulatory protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.583
EST29048.1	EST37469.1	N566_22500	N566_12885	Cellulose-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.525
EST29048.1	EST39104.1	N566_22500	N566_03875	Cellulose-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.564
EST29048.1	EST39187.1	N566_22500	N566_03380	Cellulose-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.638
EST29049.1	EST22310.1	N566_22505	N566_26690	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.607
EST29049.1	EST29048.1	N566_22505	N566_22500	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Cellulose-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.748
EST29049.1	EST32534.1	N566_22505	N566_20035	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.772
EST29049.1	EST35872.1	N566_22505	N566_17145	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.774
EST29049.1	EST37126.1	N566_22505	N566_14710	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Regulatory protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.759

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Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.889

expected number of edges:

31

PPI enrichment p-value:

0.0707

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045944

Positive regulation of transcription by RNA polymerase II

4 of 95

1.72

1.65

0.00023

GO:0000122

Negative regulation of transcription by RNA polymerase II

3 of 40

1.97

1.57

0.00075

GO:0048522

Positive regulation of cellular process

6 of 376

1.3

1.33

0.00011

GO:0006355

Regulation of transcription, DNA-templated

7 of 486

1.25

1.31

7.51e-05

GO:0000082

G1/S transition of mitotic cell cycle

2 of 12

2.31

1.23

0.0051

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000978

RNA polymerase II cis-regulatory region sequence-specific DNA binding

4 of 56

1.95

1.86

0.00016

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

4 of 144

1.54

1.3

0.0010

GO:0004693

Cyclin-dependent protein serine/threonine kinase activity

2 of 14

2.25

1.11

0.0086

GO:0003676

Nucleic acid binding

6 of 1330

0.75

0.47

0.0224

GO:1901363

Heterocyclic compound binding

8 of 2646

0.57

0.38

0.0185

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10239

Mixed, incl. CCAAT-binding factor complex, and Transcription factor GATA

3 of 12

2.49

1.89

0.00031

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-983231

Factors involved in megakaryocyte development and platelet production

3 of 54

1.84

1.01

0.0103

MAP-69017

CDK-mediated phosphorylation and removal of Cdc6

2 of 16

2.19

0.76

0.0401

MAP-69202

Cyclin E associated events during G1/S transition

2 of 19

2.12

0.75

0.0401

MAP-69052

Switching of origins to a post-replicative state

2 of 25

2.0

0.75

0.0401

MAP-109582

Hemostasis

3 of 110

1.53

0.69

0.0401

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000785

Chromatin

4 of 158

1.5

1.01

0.0058

GOCC:0043232

Intracellular non-membrane-bounded organelle

6 of 1041

0.85

0.49

0.0323

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013088

Zinc finger, NHR/GATA-type

3 of 9

2.62

1.97

0.00023

IPR000679

Zinc finger, GATA-type

3 of 10

2.57

1.97

0.00023

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00401

Zinc finger binding to DNA consensus sequence [AT]GATA[AG]

2 of 8

2.49

1.14

0.0082

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