EST39033.1 protein (Streptomycetaceae bacterium MP11305)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

EST39033.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (207 aa)

Predicted Functional Partners:

EST34842.1

0.822

EST29445.1

0.809

EST34841.1

0.742

EST39589.1

0.612

EST39035.1

0.596

EST36879.1

0.570

EST35446.1

0.563

EST38673.1

0.562

EST34760.1

0.555

EST36880.1

0.548

Your Current Organism:

Streptomycetaceae bacterium MP11305

NCBI taxonomy Id: 1380770
Other names: S. bacterium MP113-05, Streptomycetaceae bacterium MP113-05

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EST29445.1	EST34842.1	N566_22025	N566_18025	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Phage-shock protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.988
EST29445.1	EST38673.1	N566_22025	N566_06185	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.844
EST29445.1	EST39033.1	N566_22025	N566_04225	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.809
EST34760.1	EST39033.1	N566_18185	N566_04225	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.555
EST34760.1	EST39589.1	N566_18185	N566_01045	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.417
EST34841.1	EST34842.1	N566_18020	N566_18025	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Phage-shock protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.935
EST34841.1	EST39033.1	N566_18020	N566_04225	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.742
EST34841.1	EST39589.1	N566_18020	N566_01045	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.744
EST34842.1	EST29445.1	N566_18025	N566_22025	Phage-shock protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.988
EST34842.1	EST34841.1	N566_18025	N566_18020	Phage-shock protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.935
EST34842.1	EST38673.1	N566_18025	N566_06185	Phage-shock protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.533
EST34842.1	EST39033.1	N566_18025	N566_04225	Phage-shock protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.822
EST34842.1	EST39589.1	N566_18025	N566_01045	Phage-shock protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.668
EST35446.1	EST39033.1	N566_17680	N566_04225	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.563
EST36879.1	EST36880.1	N566_16000	N566_16005	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.967
EST36879.1	EST39033.1	N566_16000	N566_04225	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.570
EST36880.1	EST36879.1	N566_16005	N566_16000	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.967
EST36880.1	EST39033.1	N566_16005	N566_04225	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.548
EST38673.1	EST29445.1	N566_06185	N566_22025	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.844
EST38673.1	EST34842.1	N566_06185	N566_18025	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Phage-shock protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.533

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Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.915

expected number of edges:

25

PPI enrichment p-value:

3.41e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 121

1.37

2.32

1.11e-10

GO:0009987

Cellular process

11 of 1128

0.44

0.37

0.00061

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

8 of 61

1.57

2.73

2.61e-09

GO:0019843

rRNA binding

5 of 33

1.63

2.02

9.98e-06

GO:0003723

RNA binding

6 of 97

1.24

1.35

4.02e-05

GO:0003676

Nucleic acid binding

9 of 306

0.92

0.95

6.56e-06

GO:0003746

Translation elongation factor activity

2 of 7

1.91

0.89

0.0202

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

8 of 64

1.55

2.74

1.02e-09

GO:0044391

Ribosomal subunit

4 of 21

1.73

2.06

1.79e-05

GO:0015934

Large ribosomal subunit

3 of 10

1.93

1.89

0.00013

GO:0022625

Cytosolic large ribosomal subunit

2 of 3

2.28

1.53

0.0013

GO:0005829

Cytosol

4 of 97

1.07

0.84

0.0025

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:298

Ribosome

9 of 53

1.68

3.67

1.35e-12

CL:285

Ribosome, and Translation regulator activity

10 of 76

1.57

3.27

9.10e-13

CL:299

rRNA binding

6 of 31

1.74

2.88

3.58e-08

CL:300

rRNA-binding, and Ribosomal protein S5 domain 2-type fold, subgroup

5 of 26

1.74

2.43

1.27e-06

CL:276

Gene expression, and Helicase activity

11 of 144

1.34

2.38

9.10e-13

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

nvn03010

Ribosome

8 of 62

1.56

2.83

5.55e-10

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

3 of 22

1.59

1.11

0.0041

GOCC:1990904

Ribonucleoprotein complex

3 of 37

1.36

0.86

0.0109

GOCC:0044391

Ribosomal subunit

2 of 14

1.61

0.77

0.0278

GOCC:0022626

Cytosolic ribosome

2 of 14

1.61

0.77

0.0278

GOCC:0043229

Intracellular organelle

7 of 270

0.87

0.71

0.0011

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

8 of 62

1.56

2.78

1.00e-09

KW-0699

rRNA-binding

5 of 29

1.69

2.27

2.52e-06

KW-0251

Elongation factor

2 of 5

2.06

1.13

0.0072

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01248

Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

2 of 2

2.45

0.92

0.0208

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