EST37774.1 protein (Streptomycetaceae bacterium MP11305)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

EST37774.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (263 aa)

Predicted Functional Partners:

EST37776.1

0.745

EST21689.1

0.678

EST29048.1

0.648

EST37469.1

0.633

EST31887.1

0.631

EST22264.1

0.609

EST37537.1

0.587

EST37775.1

0.584

EST31527.1

0.580

EST35872.1

0.576

Your Current Organism:

Streptomycetaceae bacterium MP11305

NCBI taxonomy Id: 1380770
Other names: S. bacterium MP113-05, Streptomycetaceae bacterium MP113-05

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EST21689.1	EST31527.1	N566_27315	N566_20620	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.483
EST21689.1	EST31887.1	N566_27315	N566_20480	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	acyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.416
EST21689.1	EST37774.1	N566_27315	N566_11180	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.678
EST22264.1	EST29048.1	N566_26725	N566_22500	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Cellulose-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.449
EST22264.1	EST37774.1	N566_26725	N566_11180	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.609
EST29048.1	EST22264.1	N566_22500	N566_26725	Cellulose-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.449
EST29048.1	EST31527.1	N566_22500	N566_20620	Cellulose-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.554
EST29048.1	EST31887.1	N566_22500	N566_20480	Cellulose-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	acyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.435
EST29048.1	EST35872.1	N566_22500	N566_17145	Cellulose-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.668
EST29048.1	EST37469.1	N566_22500	N566_12885	Cellulose-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.525
EST29048.1	EST37774.1	N566_22500	N566_11180	Cellulose-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.648
EST31527.1	EST21689.1	N566_20620	N566_27315	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.483
EST31527.1	EST29048.1	N566_20620	N566_22500	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Cellulose-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.554
EST31527.1	EST31887.1	N566_20620	N566_20480	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	acyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.476
EST31527.1	EST35872.1	N566_20620	N566_17145	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.758
EST31527.1	EST37469.1	N566_20620	N566_12885	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.400
EST31527.1	EST37774.1	N566_20620	N566_11180	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.580
EST31887.1	EST21689.1	N566_20480	N566_27315	acyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.416
EST31887.1	EST29048.1	N566_20480	N566_22500	acyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Cellulose-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.435
EST31887.1	EST31527.1	N566_20480	N566_20620	acyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.476

page 1 of 3

Network Stats

number of nodes:

7

number of edges:

16

average node degree:

4.57

avg. local clustering coefficient:

0.952

expected number of edges:

6

PPI enrichment p-value:

0.000749

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005976

Polysaccharide metabolic process

7 of 36

1.9

3.66

9.33e-10

GO:0009250

Glucan biosynthetic process

4 of 5

2.51

3.15

1.05e-06

GO:0005975

Carbohydrate metabolic process

10 of 161

1.4

2.44

7.05e-11

GO:0005978

Glycogen biosynthetic process

3 of 4

2.48

2.28

5.42e-05

GO:0009059

Macromolecule biosynthetic process

5 of 278

0.86

0.53

0.0209

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004339

Glucan 1,4-alpha-glucosidase activity

3 of 3

2.61

2.3

5.39e-05

GO:0016757

Glycosyltransferase activity

6 of 77

1.5

1.83

1.08e-05

GO:0004553

Hydrolase activity, hydrolyzing O-glycosyl compounds

4 of 30

1.73

1.75

0.00013

GO:0030246

Carbohydrate binding

3 of 11

2.04

1.68

0.00049

GO:0016758

Hexosyltransferase activity

3 of 17

1.85

1.47

0.0010

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031470

Carboxysome

2 of 3

2.43

1.17

0.0072

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2654

Glucan metabolic process, and Glucosidase activity

9 of 13

2.45

7.86

1.36e-17

CL:2576

Mixed, incl. Polysaccharide metabolic process, and Glycosyl hydrolase, all-beta

11 of 65

1.84

5.21

1.36e-17

CL:2658

Glycogen metabolic process

4 of 5

2.51

3.39

3.44e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00500

Starch and sucrose metabolism

8 of 39

1.92

4.49

1.65e-12

map00520

Amino sugar and nucleotide sugar metabolism

4 of 54

1.48

1.35

0.00050

map00051

Fructose and mannose metabolism

2 of 20

1.61

0.75

0.0313

map01110

Biosynthesis of secondary metabolites

7 of 503

0.75

0.58

0.0022

map01100

Metabolic pathways

10 of 1398

0.46

0.37

0.0024

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0010170

glucose-1-phosphate adenylyltransferase complex

2 of 2

2.61

1.08

0.0107

GOCC:1990234

Transferase complex

4 of 104

1.19

0.78

0.0107

GOCC:0032991

Protein-containing complex

6 of 477

0.71

0.42

0.0361

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0119

Carbohydrate metabolism

3 of 14

1.94

1.41

0.0016

KW-0321

Glycogen metabolism

2 of 2

2.61

1.34

0.0036

KW-0320

Glycogen biosynthesis

2 of 3

2.43

1.3

0.0040

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00723

Glycosyl hydrolases family 15

3 of 3

2.61

2.09

0.00014

PF12804

MobA-like NTP transferase domain

3 of 10

2.08

1.55

0.0010

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005835

Nucleotidyl transferase domain

4 of 8

2.31

2.48

1.63e-05

IPR011613

GH15-like domain

3 of 3

2.61

2.02

0.00019

IPR012341

Six-hairpin glycosidase-like superfamily

3 of 6

2.31

1.8

0.00039

IPR008928

Six-hairpin glycosidase superfamily

3 of 6

2.31

1.8

0.00039

IPR029044

Nucleotide-diphospho-sugar transferases

4 of 25

1.81

1.69

0.00026

(more ...)

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