EST37072.1 protein (Streptomycetaceae bacterium MP11305)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Experiments

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[Homology]

Score

EST37072.1

Short-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (258 aa)

Predicted Functional Partners:

EST37073.1

0.956

EST38927.1

0.942

EST38552.1

0.942

EST37071.1

0.941

EST37746.1

0.917

EST39291.1

0.841

EST35964.1

0.826

EST38618.1

0.805

EST27132.1

0.795

EST37932.1

0.791

Your Current Organism:

Streptomycetaceae bacterium MP11305

NCBI taxonomy Id: 1380770
Other names: S. bacterium MP113-05, Streptomycetaceae bacterium MP113-05

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EST27132.1	EST35964.1	N566_23515	N566_16935	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.993
EST27132.1	EST37072.1	N566_23515	N566_15025	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Short-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.795
EST27132.1	EST37746.1	N566_23515	N566_11325	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.902
EST27132.1	EST37932.1	N566_23515	N566_10270	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.688
EST27132.1	EST38552.1	N566_23515	N566_06890	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.984
EST27132.1	EST38618.1	N566_23515	N566_06510	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.461
EST27132.1	EST38927.1	N566_23515	N566_04820	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.984
EST27132.1	EST39291.1	N566_23515	N566_02700	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.880
EST35964.1	EST27132.1	N566_16935	N566_23515	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.993
EST35964.1	EST37072.1	N566_16935	N566_15025	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Short-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.826
EST35964.1	EST37746.1	N566_16935	N566_11325	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.999
EST35964.1	EST37932.1	N566_16935	N566_10270	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.999
EST35964.1	EST38552.1	N566_16935	N566_06890	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.999
EST35964.1	EST38618.1	N566_16935	N566_06510	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.999
EST35964.1	EST38927.1	N566_16935	N566_04820	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.999
EST35964.1	EST39291.1	N566_16935	N566_02700	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.999
EST37071.1	EST37072.1	N566_15020	N566_15025	Threonine aldolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Short-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.941
EST37071.1	EST37073.1	N566_15020	N566_15030	Threonine aldolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.928
EST37072.1	EST27132.1	N566_15025	N566_23515	Short-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.795
EST37072.1	EST35964.1	N566_15025	N566_16935	Short-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.826

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Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.89

expected number of edges:

11

PPI enrichment p-value:

7.88e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 92

1.48

3.0

1.12e-13

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019843

rRNA binding

10 of 41

1.79

4.55

3.44e-15

GO:0003735

Structural constituent of ribosome

11 of 51

1.73

4.51

1.50e-16

GO:0000049

tRNA binding

3 of 24

1.5

0.94

0.0089

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

11 of 55

1.7

4.4

6.15e-17

GO:0044391

Ribosomal subunit

3 of 14

1.73

1.54

0.00047

GO:0015935

Small ribosomal subunit

2 of 6

1.92

1.19

0.0047

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:100

rRNA-binding

6 of 18

1.92

3.52

4.41e-09

CL:95

Structural constituent of ribosome

10 of 61

1.62

3.48

4.35e-13

CL:98

Structural constituent of ribosome

8 of 40

1.7

3.47

3.43e-11

CL:77

Mixed, incl. Ribosome, and Protein export

11 of 111

1.4

2.63

4.35e-13

CL:101

rRNA-binding

4 of 11

1.96

2.42

7.21e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

11 of 56

1.69

4.35

7.09e-17

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

9 of 43

1.72

3.79

1.74e-12

GOCC:0044391

Ribosomal subunit

5 of 17

1.87

2.81

3.39e-07

GOCC:0022626

Cytosolic ribosome

4 of 11

1.96

2.48

5.27e-06

GOCC:0022627

Cytosolic small ribosomal subunit

3 of 6

2.1

2.02

0.00010

GOCC:0043229

Intracellular organelle

10 of 223

1.05

1.34

1.16e-08

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0699

rRNA-binding

10 of 40

1.8

4.71

9.01e-16

KW-0689

Ribosomal protein

11 of 54

1.71

4.42

8.63e-17

KW-0820

tRNA-binding

3 of 12

1.8

1.5

0.00074

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