EST30342.1 protein (Streptomycetaceae bacterium MP11305)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

EST30342.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (357 aa)

Predicted Functional Partners:

EST30343.1

0.957

EST37104.1

0.651

EST31883.1

0.651

EST34576.1

0.450

EST38134.1

0.429

EST38076.1

0.403

EST26283.1

0.402

EST23504.1

0.400

Your Current Organism:

Streptomycetaceae bacterium MP11305

NCBI taxonomy Id: 1380770
Other names: S. bacterium MP113-05, Streptomycetaceae bacterium MP113-05

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structured XML interaction data, according to the 'PSI-MI' data standard

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MFA: multi-fasta format - containing the aminoacid sequences in the network

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EST23504.1	EST30342.1	N566_25620	N566_21630	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.400
EST26283.1	EST30342.1	N566_24055	N566_21630	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the glycosyl hydrolase 43 family.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.402
EST30342.1	EST23504.1	N566_21630	N566_25620	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.400
EST30342.1	EST26283.1	N566_21630	N566_24055	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the glycosyl hydrolase 43 family.	0.402
EST30342.1	EST30343.1	N566_21630	N566_21635	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.957
EST30342.1	EST31883.1	N566_21630	N566_20460	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Glycosyl transferase family 2; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.651
EST30342.1	EST34576.1	N566_21630	N566_18375	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Metallophosphoesterase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.450
EST30342.1	EST37104.1	N566_21630	N566_14780	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.651
EST30342.1	EST38076.1	N566_21630	N566_09410	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.403
EST30342.1	EST38134.1	N566_21630	N566_09105	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.429
EST30343.1	EST30342.1	N566_21635	N566_21630	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.957
EST30343.1	EST38076.1	N566_21635	N566_09410	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.435
EST31883.1	EST30342.1	N566_20460	N566_21630	Glycosyl transferase family 2; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.651
EST34576.1	EST30342.1	N566_18375	N566_21630	Metallophosphoesterase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.450
EST37104.1	EST30342.1	N566_14780	N566_21630	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.651
EST38076.1	EST30342.1	N566_09410	N566_21630	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.403
EST38076.1	EST30343.1	N566_09410	N566_21635	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.435
EST38134.1	EST30342.1	N566_09105	N566_21630	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.429

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.895

expected number of edges:

17

PPI enrichment p-value:

7.31e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009069

Serine family amino acid metabolic process

4 of 25

2.08

2.47

9.15e-06

GO:0006544

Glycine metabolic process

3 of 6

2.58

2.45

2.69e-05

GO:0019752

Carboxylic acid metabolic process

9 of 281

1.38

2.18

4.60e-09

GO:0006520

Cellular amino acid metabolic process

6 of 170

1.43

1.74

9.15e-06

GO:1901605

Alpha-amino acid metabolic process

5 of 123

1.49

1.63

5.61e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019842

Vitamin binding

3 of 51

1.65

0.86

0.0184

GO:0046872

Metal ion binding

6 of 555

0.91

0.57

0.0184

GO:0036094

Small molecule binding

6 of 819

0.74

0.42

0.0432

GO:0003824

Catalytic activity

11 of 3149

0.42

0.31

0.0184

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

5 of 319

1.07

0.87

0.0019

GO:0043231

Intracellular membrane-bounded organelle

3 of 96

1.37

0.86

0.0107

GO:0005737

Cytoplasm

10 of 1478

0.71

0.64

5.18e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:632

Mixed, incl. Carbon metabolism, and Valine, leucine and isoleucine biosynthesis

6 of 138

1.52

1.81

1.62e-05

CL:636

Mixed, incl. Citrate cycle (TCA cycle), and Alpha-amino acid catabolic process

4 of 48

1.8

1.64

0.00034

CL:880

Mixed, incl. FAD-linked oxidase-like, C-terminal, and Phosphoglycolate phosphatase-like, domain 2

2 of 10

2.18

0.85

0.0268

CL:705

Glycine metabolic process, and acetyl-CoA biosynthetic process from pyruvate

2 of 11

2.14

0.84

0.0271

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00260

Glycine, serine and threonine metabolism

3 of 35

1.81

1.34

0.0018

map01200

Carbon metabolism

4 of 136

1.35

1.09

0.0018

map01110

Biosynthesis of secondary metabolites

6 of 707

0.81

0.6

0.0040

map01100

Metabolic pathways

9 of 1973

0.54

0.41

0.0036

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005777

Peroxisome

3 of 8

2.45

2.32

4.25e-05

GOCC:0009514

Glyoxysome

2 of 2

2.88

1.79

0.00057

GOCC:0005737

Cytoplasm

10 of 1152

0.82

0.8

8.02e-06

GOCC:0043231

Intracellular membrane-bounded organelle

4 of 247

1.09

0.71

0.0114

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00463

Isocitrate lyase family

2 of 2

2.88

1.18

0.0074

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039556

ICL/PEPM domain

2 of 2

2.88

0.97

0.0181

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