EST23402.1 protein (Streptomycetaceae bacterium MP11305)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

EST23402.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (181 aa)

Predicted Functional Partners:

EST21064.1

0.770

EST39592.1

0.769

EST28387.1

0.768

EST38636.1

0.748

EST23403.1

0.703

EST34042.1

0.702

EST23401.1

0.662

EST34838.1

0.637

EST35646.1

0.634

EST38880.1

0.633

Your Current Organism:

Streptomycetaceae bacterium MP11305

NCBI taxonomy Id: 1380770
Other names: S. bacterium MP113-05, Streptomycetaceae bacterium MP113-05

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EST21064.1	EST23402.1	N566_27770	N566_25810	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.770
EST21064.1	EST34042.1	N566_27770	N566_18980	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.428
EST21064.1	EST34838.1	N566_27770	N566_18045	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.403
EST21064.1	EST38636.1	N566_27770	N566_06295	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Anti-sigma regulatory factor; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.711
EST21064.1	EST38880.1	N566_27770	N566_05080	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.617
EST23401.1	EST23402.1	N566_25805	N566_25810	Suppressor of fused domain protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.662
EST23401.1	EST23403.1	N566_25805	N566_25815	Suppressor of fused domain protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Phosphoesterase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.592
EST23402.1	EST21064.1	N566_25810	N566_27770	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.770
EST23402.1	EST23401.1	N566_25810	N566_25805	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Suppressor of fused domain protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.662
EST23402.1	EST23403.1	N566_25810	N566_25815	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Phosphoesterase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.703
EST23402.1	EST28387.1	N566_25810	N566_22820	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.768
EST23402.1	EST34042.1	N566_25810	N566_18980	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.702
EST23402.1	EST34838.1	N566_25810	N566_18045	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.637
EST23402.1	EST35646.1	N566_25810	N566_17440	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.634
EST23402.1	EST38636.1	N566_25810	N566_06295	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Anti-sigma regulatory factor; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.748
EST23402.1	EST38880.1	N566_25810	N566_05080	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.633
EST23402.1	EST39592.1	N566_25810	N566_01060	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Sporulation protein SsgA; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.769
EST23403.1	EST23401.1	N566_25815	N566_25805	Phosphoesterase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Suppressor of fused domain protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.592
EST23403.1	EST23402.1	N566_25815	N566_25810	Phosphoesterase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.703
EST28387.1	EST23402.1	N566_22820	N566_25810	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.768

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Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.949

expected number of edges:

23

PPI enrichment p-value:

5.57e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042274

Ribosomal small subunit biogenesis

6 of 59

1.95

3.11

9.96e-08

GO:0042254

Ribosome biogenesis

8 of 250

1.45

2.15

9.96e-08

GO:0000462

Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

3 of 27

1.99

1.41

0.0017

GO:0006364

rRNA processing

5 of 187

1.37

1.22

0.00075

GO:0006412

Translation

5 of 264

1.22

0.97

0.0022

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

5 of 143

1.49

1.37

0.00047

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022627

Cytosolic small ribosomal subunit

4 of 19

2.27

2.68

5.69e-06

GO:0030688

Preribosome, small subunit precursor

3 of 10

2.42

2.29

4.86e-05

GO:0030684

Preribosome

4 of 78

1.65

1.7

0.00012

GO:0005840

Ribosome

5 of 151

1.47

1.61

5.22e-05

GO:1990904

Ribonucleoprotein complex

7 of 382

1.21

1.35

1.65e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4381

Cytosolic small ribosomal subunit, and GTP hydrolysis and joining of the 60S ribosomal subunit

5 of 20

2.34

3.67

5.20e-08

CL:5063

Preribosome, small subunit precursor, and RIO kinase

4 of 10

2.55

3.25

6.82e-07

CL:5066

Preribosome, small subunit precursor, and rRNA-binding

3 of 5

2.72

2.77

7.73e-06

CL:4383

Cytosolic small ribosomal subunit, and Ribosomal protein L2, domain 2

3 of 13

2.31

2.2

6.15e-05

CL:4397

Mixed, incl. Ribosomal protein S8, and Ribosomal protein S5/S7

2 of 6

2.47

1.41

0.0025

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

5 of 167

1.42

1.49

0.00010

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

9 of 124

1.81

4.19

6.50e-13

MAP-8868773

rRNA processing in the nucleus and cytosol

9 of 128

1.79

4.14

6.50e-13

MAP-72312

rRNA processing

9 of 132

1.78

4.08

6.50e-13

MAP-72695

Formation of the ternary complex, and subsequently, the 43S complex

5 of 59

1.87

2.67

8.88e-07

MAP-72702

Ribosomal scanning and start codon recognition

5 of 65

1.83

2.57

1.17e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0022627

Cytosolic small ribosomal subunit

5 of 26

2.23

3.45

9.71e-08

GOCC:0030688

Preribosome, small subunit precursor

3 of 13

2.31

2.15

7.73e-05

GOCC:1990904

Ribonucleoprotein complex

8 of 374

1.28

1.7

3.59e-07

GOCC:0032991

Protein-containing complex

9 of 1912

0.62

0.48

0.0017

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

5 of 49

1.95

2.87

4.66e-07

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