node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KRN55086.1 | KRN55579.1 | IV72_GL000586 | IV72_GL001106 | Inosine 5-monophosphate dehydrogenase. | Non-canonical purine NTP pyrophosphatase, RdgB HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.950 |
KRN55086.1 | KRN55593.1 | IV72_GL000586 | IV72_GL001120 | Inosine 5-monophosphate dehydrogenase. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.949 |
KRN55086.1 | KRN55618.1 | IV72_GL000586 | IV72_GL001145 | Inosine 5-monophosphate dehydrogenase. | Transporter, HlyC CorC family. | 0.636 |
KRN55086.1 | KRN55716.1 | IV72_GL000586 | IV72_GL001249 | Inosine 5-monophosphate dehydrogenase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase. | 0.965 |
KRN55086.1 | apt | IV72_GL000586 | IV72_GL000466 | Inosine 5-monophosphate dehydrogenase. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.939 |
KRN55086.1 | guaA | IV72_GL000586 | IV72_GL000339 | Inosine 5-monophosphate dehydrogenase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.998 |
KRN55086.1 | purA | IV72_GL000586 | IV72_GL001175 | Inosine 5-monophosphate dehydrogenase. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.984 |
KRN55579.1 | KRN55086.1 | IV72_GL001106 | IV72_GL000586 | Non-canonical purine NTP pyrophosphatase, RdgB HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine 5-monophosphate dehydrogenase. | 0.950 |
KRN55579.1 | KRN55593.1 | IV72_GL001106 | IV72_GL001120 | Non-canonical purine NTP pyrophosphatase, RdgB HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.913 |
KRN55579.1 | KRN55618.1 | IV72_GL001106 | IV72_GL001145 | Non-canonical purine NTP pyrophosphatase, RdgB HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Transporter, HlyC CorC family. | 0.543 |
KRN55579.1 | KRN55716.1 | IV72_GL001106 | IV72_GL001249 | Non-canonical purine NTP pyrophosphatase, RdgB HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase. | 0.577 |
KRN55579.1 | apt | IV72_GL001106 | IV72_GL000466 | Non-canonical purine NTP pyrophosphatase, RdgB HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.634 |
KRN55579.1 | guaA | IV72_GL001106 | IV72_GL000339 | Non-canonical purine NTP pyrophosphatase, RdgB HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.974 |
KRN55579.1 | purA | IV72_GL001106 | IV72_GL001175 | Non-canonical purine NTP pyrophosphatase, RdgB HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.824 |
KRN55593.1 | KRN55086.1 | IV72_GL001120 | IV72_GL000586 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine 5-monophosphate dehydrogenase. | 0.949 |
KRN55593.1 | KRN55579.1 | IV72_GL001120 | IV72_GL001106 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Non-canonical purine NTP pyrophosphatase, RdgB HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.913 |
KRN55593.1 | KRN55618.1 | IV72_GL001120 | IV72_GL001145 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Transporter, HlyC CorC family. | 0.567 |
KRN55593.1 | KRN55716.1 | IV72_GL001120 | IV72_GL001249 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase. | 0.931 |
KRN55593.1 | apt | IV72_GL001120 | IV72_GL000466 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.954 |
KRN55593.1 | guaA | IV72_GL001120 | IV72_GL000339 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.969 |