STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DSY3648Hypothetical protein; Belongs to the trimethylamine methyltransferase family. (468 aa)    
Predicted Functional Partners:
DSY0986
Hypothetical protein; Similarity to COG0407 Uroporphyrinogen-III decarboxylase.
  
  
 0.937
mtgA
Hypothetical protein; Methyltransferase able to catalyze the transfer of a methyl group from methylcobalamin (methylCbl) to tetrahydrofolate (THF) in vitro, to generate methyl-THF and cob(I)alamin. In vivo, the methyl group probably comes from the adjacently encoded methylated corrinoid protein DSY3155. The methyl group may then be ultimately converted to carbon dioxide, and its oxidation would also provide reducing equivalents for anaerobic respiration. Thus, may function in the pathway that allows anaerobic methylotrophic growth of D.hafniense using glycine betaine.
 
  
  0.932
DSY4970
Hypothetical protein; Catalyzes the transfer of a methyl group from trimethylamine to the corrinoid cofactor of MttC.
  
  
 
0.922
DSY3155
Hypothetical protein; Probably harbors a corrinoid prosthetic group and acts as a methyl group carrier between MtgB and MtgA. A methyl group from glycine betaine is likely first transferred to the corrinoid prosthetic group of the enzyme by MtgB, and then transferred to tetrahydrofolate (THF) by MtgA. The methyl group may then be ultimately converted to carbon dioxide, and its oxidation would also provide reducing equivalents for anaerobic respiration. Thus, may function in the pathway that allows anaerobic methylotrophic growth of D.hafniense using glycine betaine.
  
 0.917
DSY4971
Hypothetical protein; Belongs to the trimethylamine methyltransferase family.
  
  
 
0.914
mtgB
Hypothetical protein; Methyltransferase able to methylate free cob(I)alamin in vitro, using glycine betaine as the methyl donor, yealding methylcobalamin (methylCbl) and dimethylglycine. In vivo, probably carries out the methylation of a corrinoid protein, likely the adjacently encoded DSY3155, with glycine betaine, to then supply methyl groups to tetrahydrofolate (THF) for ultimate conversion to carbon dioxide; oxidation of the methyl group would also provide reducing equivalents for anaerobic respiration. Thus, may function in the pathway that allows anaerobic methylotrophic growth o [...]
  
  
 
0.905
DSY0249
Hypothetical protein; Similarity to COG1410 Methionine synthase I, cobalamin-binding domain(Evalue: 1E-25).
    
 0.901
DSY3645
Hypothetical protein; Similarity to COG0145 N-methylhydantoinase A(Evalue: 2E-90).
 
     0.841
DSY2130
Hypothetical protein; Similarity to COG0633 Ferredoxin.
 
     0.752
DSY3152
Hypothetical protein; Similarity to COG2871 Na+-transporting NADH:ubiquinone oxidoreductase beta subunit.
 
     0.751
Your Current Organism:
Desulfitobacterium hafniense
NCBI taxonomy Id: 138119
Other names: D. hafniense Y51, Desulfitobacterium hafniense Y51, Desulfitobacterium hafniense str. Y51, Desulfitobacterium hafniense strain Y51, Desulfitobacterium sp. Y51
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