KJB94425.1 protein (Skermanella aerolata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

KJB94425.1

C4-dicarboxylate ABC transporter; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (427 aa)

Predicted Functional Partners:

KJB94426.1

0.979

KJB94427.1

0.947

KJB94422.1

0.938

KJB94423.1

0.915

KJB96666.1

0.875

KJB90584.1

0.875

KJB92603.1

0.869

KJB95712.1

0.867

KJB96734.1

0.865

KJB92439.1

0.861

Your Current Organism:

Skermanella aerolata

NCBI taxonomy Id: 1385368
Other names: S. aerolata KACC 11604, Skermanella aerolata 5416T-32, Skermanella aerolata DSM 18479, Skermanella aerolata KACC 11604

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KJB90584.1	KJB94422.1	N826_38655	N826_11660	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.870
KJB90584.1	KJB94425.1	N826_38655	N826_11675	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	C4-dicarboxylate ABC transporter; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.875
KJB90584.1	KJB94426.1	N826_38655	N826_11680	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.870
KJB90584.1	KJB96666.1	N826_38655	N826_32930	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.846
KJB92439.1	KJB94422.1	N826_23000	N826_11660	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.870
KJB92439.1	KJB94425.1	N826_23000	N826_11675	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	C4-dicarboxylate ABC transporter; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.861
KJB92439.1	KJB94426.1	N826_23000	N826_11680	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.869
KJB92439.1	KJB96666.1	N826_23000	N826_32930	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.832
KJB92603.1	KJB94422.1	N826_21680	N826_11660	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.870
KJB92603.1	KJB94425.1	N826_21680	N826_11675	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	C4-dicarboxylate ABC transporter; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.869
KJB92603.1	KJB94426.1	N826_21680	N826_11680	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.869
KJB92603.1	KJB96666.1	N826_21680	N826_32930	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.831
KJB94422.1	KJB90584.1	N826_11660	N826_38655	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.870
KJB94422.1	KJB92439.1	N826_11660	N826_23000	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.870
KJB94422.1	KJB92603.1	N826_11660	N826_21680	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.870
KJB94422.1	KJB94423.1	N826_11660	N826_11665	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.940
KJB94422.1	KJB94425.1	N826_11660	N826_11675	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	C4-dicarboxylate ABC transporter; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.938
KJB94422.1	KJB94426.1	N826_11660	N826_11680	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.656
KJB94422.1	KJB94427.1	N826_11660	N826_11685	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.909
KJB94422.1	KJB95712.1	N826_11660	N826_40040	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.871

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Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.865

expected number of edges:

11

PPI enrichment p-value:

0.000495

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006368

Transcription elongation from RNA polymerase II promoter

6 of 24

2.31

4.32

1.40e-09

GO:0016570

Histone modification

6 of 92

1.72

2.48

7.50e-07

GO:0032968

Positive regulation of transcription elongation from RNA polymerase II promoter

3 of 13

2.27

1.94

0.00020

GO:0034402

Recruitment of 3-end processing factors to RNA polymerase II holoenzyme complex

2 of 5

2.51

1.32

0.0038

GO:0070478

Nuclear-transcribed mRNA catabolic process, 3-5 exonucleolytic nonsense-mediated decay

2 of 8

2.31

1.15

0.0074

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000993

RNA polymerase II complex binding

6 of 14

2.54

5.28

3.99e-11

GO:0005515

Protein binding

8 of 738

0.94

0.91

6.82e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016593

Cdc73/Paf1 complex

6 of 8

2.78

6.18

1.66e-12

GO:0055087

Ski complex

2 of 3

2.73

1.65

0.00096

GO:0032991

Protein-containing complex

10 of 1771

0.66

0.58

8.35e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1768

RNA Polymerase II Transcription Elongation

6 of 28

2.24

4.23

1.43e-09

CL:1810

Cdc73/Paf1 complex

4 of 6

2.73

3.73

1.06e-07

CL:681

COP9 signalosome, and Cul4-RING E3 ubiquitin ligase complex

3 of 20

2.08

1.72

0.00044

CL:5095

mRNA decay by 3 to 5 exoribonuclease

2 of 17

1.98

0.8

0.0316

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-75955

RNA Polymerase II Transcription Elongation

6 of 43

2.05

3.65

8.49e-09

MAP-674695

RNA Polymerase II Pre-transcription Events

6 of 67

1.86

3.06

5.11e-08

MAP-73857

RNA Polymerase II Transcription

6 of 389

1.1

0.95

0.00087

MAP-74160

Gene expression (Transcription)

6 of 523

0.97

0.73

0.0035

MAP-8866654

E3 ubiquitin ligases ubiquitinate target proteins

2 of 17

1.98

0.73

0.0435

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016593

Cdc73/Paf1 complex

6 of 8

2.78

6.15

1.92e-12

GOCC:0055087

Ski complex

2 of 2

2.91

1.71

0.00080

GOCC:0032991

Protein-containing complex

9 of 2171

0.53

0.38

0.0083

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