KGN28842.1 protein (Knoellia flava) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

KGN28842.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (122 aa)

Predicted Functional Partners:

gatC

0.556

KGN28777.1

0.476

KGN28778.1

0.476

KGN28779.1

0.476

KGN28780.1

0.476

Your Current Organism:

Knoellia flava

NCBI taxonomy Id: 1385518
Other names: K. flava TL1, Knoellia flava TL1, Knoellia sp. TL1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KGN28777.1	KGN28778.1	N798_17180	N798_17185	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.994
KGN28777.1	KGN28779.1	N798_17180	N798_17190	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Tripartite tricarboxylate transporter TctA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.994
KGN28777.1	KGN28780.1	N798_17180	N798_17195	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Universal stress protein UspA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.829
KGN28777.1	KGN28842.1	N798_17180	N798_17200	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.476
KGN28778.1	KGN28777.1	N798_17185	N798_17180	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.994
KGN28778.1	KGN28779.1	N798_17185	N798_17190	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Tripartite tricarboxylate transporter TctA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.994
KGN28778.1	KGN28780.1	N798_17185	N798_17195	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Universal stress protein UspA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.853
KGN28778.1	KGN28842.1	N798_17185	N798_17200	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.476
KGN28779.1	KGN28777.1	N798_17190	N798_17180	Tripartite tricarboxylate transporter TctA; Derived by automated computational analysis using gene prediction method: Protein Homology.	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.994
KGN28779.1	KGN28778.1	N798_17190	N798_17185	Tripartite tricarboxylate transporter TctA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.994
KGN28779.1	KGN28780.1	N798_17190	N798_17195	Tripartite tricarboxylate transporter TctA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Universal stress protein UspA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.829
KGN28779.1	KGN28842.1	N798_17190	N798_17200	Tripartite tricarboxylate transporter TctA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.476
KGN28780.1	KGN28777.1	N798_17195	N798_17180	Universal stress protein UspA; Derived by automated computational analysis using gene prediction method: Protein Homology.	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.829
KGN28780.1	KGN28778.1	N798_17195	N798_17185	Universal stress protein UspA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.853
KGN28780.1	KGN28779.1	N798_17195	N798_17190	Universal stress protein UspA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Tripartite tricarboxylate transporter TctA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.829
KGN28780.1	KGN28842.1	N798_17195	N798_17200	Universal stress protein UspA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.476
KGN28842.1	KGN28777.1	N798_17200	N798_17180	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	C4-dicarboxylate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.476
KGN28842.1	KGN28778.1	N798_17200	N798_17185	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.476
KGN28842.1	KGN28779.1	N798_17200	N798_17190	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Tripartite tricarboxylate transporter TctA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.476
KGN28842.1	KGN28780.1	N798_17200	N798_17195	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Universal stress protein UspA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.476

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.849

expected number of edges:

16

PPI enrichment p-value:

2.04e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046294

Formaldehyde catabolic process

5 of 11

3.08

5.6

4.89e-11

GO:0070887

Cellular response to chemical stimulus

7 of 1276

1.16

1.25

2.93e-05

GO:0050896

Response to stimulus

10 of 4379

0.78

0.74

2.04e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051903

S-(hydroxymethyl)glutathione dehydrogenase activity

5 of 10

3.12

6.12

5.35e-12

GO:0004024

Alcohol dehydrogenase activity, zinc-dependent

5 of 16

2.92

5.66

2.72e-11

GO:0016616

Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

8 of 162

2.12

5.28

3.79e-13

GO:0004032

alditol:NADP+ 1-oxidoreductase activity

3 of 8

3.0

3.17

1.66e-06

GO:0004737

Pyruvate decarboxylase activity

2 of 2

3.42

2.14

0.00014

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

10 of 1687

1.19

1.7

3.76e-09

GO:0005737

Cytoplasm

11 of 9767

0.47

0.38

0.0025

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:28511694

(2017) Ethephon induced oxidative stress in the olive leaf abscission zone enables development of a selective abscission compound.

4 of 48

2.34

2.69

6.37e-06

PMID:32736517

(2020) Physiological and transcriptome analysis of Poa pratensis var. anceps cv. Qinghai in response to cold stress.

4 of 59

2.25

2.63

6.99e-06

PMID:31993137

(2020) Dynamics of ADH and related genes responsible for the transformation of C6-aldehydes to C6-alcohols during the postharvest process of oolong tea.

2 of 2

3.42

1.81

0.00056

PMID:36519164

(2022) New insights into immunomodulatory properties of lactic acid bacteria fermented herbal medicines.

2 of 4

3.12

1.66

0.0010

PMID:37663261

(2023) Natural products target glycolysis in liver disease.

2 of 33

2.2

0.8

0.0329

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8670

Mixed, incl. Formaldehyde metabolic process, and Aldo-keto reductase family 4C

11 of 19

3.18

15.79

7.52e-31

CL:8673

Aldo-keto reductase family 4C, and S-(hydroxymethyl)glutathione dehydrogenase activity

10 of 11

3.38

15.22

4.69e-29

CL:8678

S-(hydroxymethyl)glutathione dehydrogenase activity

5 of 5

3.42

6.77

4.80e-13

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

dct00010

Glycolysis / Gluconeogenesis

11 of 86

2.53

11.36

4.17e-26

dct00350

Tyrosine metabolism

5 of 32

2.62

5.37

3.78e-11

dct00071

Fatty acid degradation

5 of 36

2.56

5.26

5.20e-11

dct01110

Biosynthesis of secondary metabolites

11 of 829

1.54

3.5

7.23e-16

dct00040

Pentose and glucuronate interconversions

4 of 56

2.28

3.45

1.16e-07

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-71384

Ethanol oxidation

5 of 19

2.84

5.35

9.24e-11

MAP-211945

Phase I - Functionalization of compounds

5 of 342

1.59

1.83

2.79e-05

MAP-211859

Biological oxidations

5 of 407

1.51

1.68

4.90e-05

MAP-1430728

Metabolism

9 of 2303

1.01

1.13

2.44e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005920

Smooth septate junction

2 of 4

3.12

1.45

0.0024

GOCC:0005829

Cytosol

5 of 841

1.2

0.94

0.0024

GOCC:0005737

Cytoplasm

10 of 7329

0.56

0.43

0.0024

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0786

Thiamine pyrophosphate

2 of 13

2.61

1.32

0.0039

KW-0670

Pyruvate

2 of 74

1.85

0.76

0.0350

KW-0479

Metal-binding

6 of 1848

0.93

0.7

0.0039

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08240

Alcohol dehydrogenase GroES-like domain

5 of 35

2.58

4.42

3.10e-09

PF00107

Zinc-binding dehydrogenase

4 of 18

2.77

3.83

7.17e-08

PF00248

Aldo/keto reductase family

4 of 24

2.64

3.65

1.34e-07

PF00205

Thiamine pyrophosphate enzyme, central domain

2 of 4

3.12

1.7

0.00086

PF02776

Thiamine pyrophosphate enzyme, N-terminal TPP binding domain

2 of 5

3.02

1.67

0.00097

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002328

Alcohol dehydrogenase, zinc-type, conserved site

5 of 18

2.87

5.0

4.70e-10

IPR013154

Alcohol dehydrogenase-like, N-terminal

5 of 35

2.58

4.34

4.58e-09

IPR018170

Aldo/keto reductase, conserved site

4 of 10

3.02

4.22

1.77e-08

IPR020471

Aldo-keto reductase

4 of 13

2.91

4.09

2.76e-08

IPR011032

GroES-like superfamily

5 of 51

2.41

3.94

1.77e-08

(more ...)

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