KGN28807.1 protein (Knoellia flava) - STRING interaction network

Nodes:

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

KGN28807.1

2-isopropylmalate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (149 aa)

Predicted Functional Partners:

KGN28806.1

0.618

KGN28847.1

0.618

KGN35356.1

0.612

KGN33441.1

0.461

KGN29936.1

0.401

Your Current Organism:

Knoellia flava

NCBI taxonomy Id: 1385518
Other names: K. flava TL1, Knoellia flava TL1, Knoellia sp. TL1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KGN28806.1	KGN28807.1	N798_17350	N798_17360	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-isopropylmalate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.618
KGN28806.1	KGN28847.1	N798_17350	N798_17355	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.777
KGN28807.1	KGN28806.1	N798_17360	N798_17350	2-isopropylmalate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.618
KGN28807.1	KGN28847.1	N798_17360	N798_17355	2-isopropylmalate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.618
KGN28807.1	KGN29936.1	N798_17360	N798_12120	2-isopropylmalate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.401
KGN28807.1	KGN33441.1	N798_17360	N798_05535	2-isopropylmalate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.461
KGN28807.1	KGN35356.1	N798_17360	N798_03270	2-isopropylmalate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Polyketide cyclase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.612
KGN28847.1	KGN28806.1	N798_17355	N798_17350	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.777
KGN28847.1	KGN28807.1	N798_17355	N798_17360	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	2-isopropylmalate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.618
KGN29936.1	KGN28807.1	N798_12120	N798_17360	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	2-isopropylmalate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.401
KGN33441.1	KGN28807.1	N798_05535	N798_17360	Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-isopropylmalate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.461
KGN35356.1	KGN28807.1	N798_03270	N798_17360	Polyketide cyclase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	2-isopropylmalate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.612

Network Stats

number of nodes:

3

number of edges:

3

average node degree:

2

avg. local clustering coefficient:

1

expected number of edges:

2

PPI enrichment p-value:

0.213

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1902600

Proton transmembrane transport

5 of 45

1.91

2.6

1.86e-06

GO:0044237

Cellular metabolic process

11 of 2827

0.45

0.37

0.0017

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015453

Oxidoreduction-driven active transmembrane transporter activity

8 of 48

2.08

5.24

2.61e-13

GO:0009055

Electron transfer activity

10 of 148

1.69

3.92

6.84e-14

GO:0016675

Oxidoreductase activity, acting on a heme group of donors

5 of 25

2.16

3.55

3.77e-08

GO:0016679

Oxidoreductase activity, acting on diphenols and related substances as donors

4 of 9

2.51

3.51

1.88e-07

GO:0004129

Cytochrome-c oxidase activity

4 of 21

2.14

2.73

2.88e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070469

Respirasome

3 of 20

2.04

1.64

0.00059

GO:0005886

Plasma membrane

8 of 1351

0.64

0.47

0.0047

GO:0016021

Integral component of membrane

9 of 1807

0.56

0.42

0.0047

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6359

Oxidoreduction-driven active transmembrane transporter activity, and Cytochrome c

10 of 49

2.17

7.11

2.00e-18

CL:6364

Mixed, incl. Cytochrome-c oxidase activity, and Oxidoreductase activity, acting on diphenols and related substances as donors

8 of 36

2.21

6.0

1.81e-14

CL:6356

Oxidative phosphorylation, and Cytochrome c

11 of 95

1.93

5.86

2.00e-18

CL:6366

Oxidoreduction-driven active transmembrane transporter activity, and Peptidase M16 inactive domain

7 of 25

2.31

5.73

5.18e-13

CL:6397

Respiratory chain, and Insulinase (Peptidase family M16)

3 of 7

2.49

2.36

3.68e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

9 of 101

1.81

4.39

9.07e-14

map01100

Metabolic pathways

11 of 2600

0.49

0.41

0.00029

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070469

Respirasome

6 of 66

1.82

2.94

7.36e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0679

Respiratory chain

2 of 11

2.12

0.95

0.0167

KW-0349

Heme

3 of 80

1.44

0.82

0.0167

KW-0408

Iron

4 of 169

1.24

0.75

0.0155

KW-0479

Metal-binding

5 of 428

0.93

0.59

0.0167

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00116

Cytochrome C oxidase subunit II, periplasmic domain

4 of 4

2.86

3.73

1.30e-07

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