STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
recQ_1ATP-dependent DNA helicase RecQ; Ab initio prediction:Prodigal:2.6; similar to AA sequence:UniProtKB:P15043. (491 aa)    
Predicted Functional Partners:
topA
DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 0.976
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.958
recJ
Single-stranded-DNA-specific exonuclease RecJ; Ab initio prediction:Prodigal:2.6; similar to AA sequence:UniProtKB:P21893.
   
 0.933
yhaO
Putative metallophosphoesterase YhaO; Ab initio prediction:Prodigal:2.6; similar to AA sequence:UniProtKB:O07522.
  
 0.930
recA
Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.928
APW59076.1
Hypothetical protein; Ab initio prediction:Prodigal:2.6.
  
 0.905
APW62480.1
Hypothetical protein; Ab initio prediction:Prodigal:2.6; similar to AA sequence:UniProtKB:P9WMR5; Probable ATP-dependent helicase DinG homolog.
 
 0.892
mutL
DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
  
 0.851
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
 
  
   0.841
pcrA_2
ATP-dependent DNA helicase PcrA; Ab initio prediction:Prodigal:2.6; similar to AA sequence:UniProtKB:O34580.
 
 
 0.832
Your Current Organism:
Paludisphaera borealis
NCBI taxonomy Id: 1387353
Other names: DSM 28747, Isosphaera sp. PX4, P. borealis, Paludisphaera borealis Kulichevskaya et al. 2016, Planctomycetaceae bacterium PT1, VKM B-2904, strain PX4
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