STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnaK_4Chaperone protein DnaK; Ab initio prediction:Prodigal:2.6; similar to AA sequence:UniProtKB:O52960. (959 aa)    
Predicted Functional Partners:
htpG
Chaperone protein HtpG; Molecular chaperone. Has ATPase activity.
   
 0.972
grpE_1
Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
 
 0.930
grpE_2
Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
 
 0.930
rpoA_2
DNA-directed RNA polymerase subunit alpha; Ab initio prediction:Prodigal:2.6; similar to AA sequence:UniProtKB:Q664U6.
  
 0.843
rplP
50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family.
   
 
 0.811
dnaJ_2
Chaperone protein DnaJ; Ab initio prediction:Prodigal:2.6; similar to AA sequence:UniProtKB:P28616.
  
 0.805
APW60561.1
Hypothetical protein; Ab initio prediction:Prodigal:2.6.
  
 0.805
dnaJ_4
Chaperone protein DnaJ; Ab initio prediction:Prodigal:2.6; similar to AA sequence:UniProtKB:P08622.
  
 0.805
dnaJ_5
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
 0.805
APW62726.1
Hypothetical protein; Ab initio prediction:Prodigal:2.6.
 
     0.788
Your Current Organism:
Paludisphaera borealis
NCBI taxonomy Id: 1387353
Other names: DSM 28747, Isosphaera sp. PX4, P. borealis, Paludisphaera borealis Kulichevskaya et al. 2016, Planctomycetaceae bacterium PT1, VKM B-2904, strain PX4
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.