STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisA_21-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Ab initio prediction:Prodigal:2.6; similar to AA sequence:UniProtKB:P10372. (243 aa)    
Predicted Functional Partners:
hisI
Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
 0.999
hisF
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
0.999
hisH1
Imidazole glycerol phosphate synthase subunit HisH 1; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
 0.999
hisB
Imidazoleglycerol-phosphate dehydratase; Ab initio prediction:Prodigal:2.6; similar to AA sequence:UniProtKB:A0QX83.
  
 0.985
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
 
  
 0.977
hpsN
Sulfopropanediol 3-dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.971
hisA_1
1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Ab initio prediction:Prodigal:2.6; similar to AA sequence:UniProtKB:A1R562; Belongs to the HisA/HisF family.
  
  
0.940
hisC_2
Histidinol-phosphate aminotransferase; Ab initio prediction:Prodigal:2.6; similar to AA sequence:UniProtKB:Q39YP6; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.875
hisC_1
Histidinol-phosphate aminotransferase; Ab initio prediction:Prodigal:2.6; similar to AA sequence:UniProtKB:Q9KJU4.
 
  
 0.843
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
  
 0.842
Your Current Organism:
Paludisphaera borealis
NCBI taxonomy Id: 1387353
Other names: DSM 28747, Isosphaera sp. PX4, P. borealis, Paludisphaera borealis Kulichevskaya et al. 2016, Planctomycetaceae bacterium PT1, VKM B-2904, strain PX4
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