STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pdhC_2Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Ab initio prediction:Prodigal:2.6; similar to AA sequence:UniProtKB:P65636. (434 aa)    
Predicted Functional Partners:
bfmBAB_2
2-oxoisovalerate dehydrogenase subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 0.999
lpd3_2
Dihydrolipoyl dehydrogenase 3; Ab initio prediction:Prodigal:2.6; similar to AA sequence:UniProtKB:P31046.
 0.998
acoA_2
Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 0.998
lpd3_1
Dihydrolipoyl dehydrogenase 3; Ab initio prediction:Prodigal:2.6; similar to AA sequence:UniProtKB:P31046.
 0.997
bfmBAB_1
2-oxoisovalerate dehydrogenase subunit beta; Ab initio prediction:Prodigal:2.6; similar to AA sequence:UniProtKB:P37941.
 0.994
kgd
Multifunctional 2-oxoglutarate metabolism enzyme; Ab initio prediction:Prodigal:2.6; similar to AA sequence:UniProtKB:A0R2B1.
 0.989
acoA_1
Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha; Ab initio prediction:Prodigal:2.6; similar to AA sequence:UniProtKB:O31404.
 0.977
gltA2
Citrate synthase 1; Ab initio prediction:Prodigal:2.6; similar to AA sequence:UniProtKB:P9WPD5; Belongs to the citrate synthase family.
  
 0.960
sucC
Succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.954
sucD_4
Succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.950
Your Current Organism:
Paludisphaera borealis
NCBI taxonomy Id: 1387353
Other names: DSM 28747, Isosphaera sp. PX4, P. borealis, Paludisphaera borealis Kulichevskaya et al. 2016, Planctomycetaceae bacterium PT1, VKM B-2904, strain PX4
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