node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AIN56794.1 | argA | O165_000130 | O165_022005 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | N-acetylglutamate synthase; Catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.810 |
AIN56794.1 | argH | O165_000130 | O165_022425 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Argininosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.966 |
AIN56794.1 | argJ | O165_000130 | O165_028650 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Ornithine acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. | 0.439 |
AIN56794.1 | gltA | O165_000130 | O165_014750 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. | 0.989 |
AIN56794.1 | oadA | O165_000130 | O165_022885 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Pyruvate carboxylase subunit B; Catalyzes the formation of oxaloacetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.986 |
AIN56794.1 | sdhB | O165_000130 | O165_014730 | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.996 |
AIN57881.1 | argA | O165_006050 | O165_022005 | Adenylosuccinate lyase; Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | N-acetylglutamate synthase; Catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.422 |
AIN57881.1 | argH | O165_006050 | O165_022425 | Adenylosuccinate lyase; Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Argininosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.945 |
AIN57881.1 | oadA | O165_006050 | O165_022885 | Adenylosuccinate lyase; Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Pyruvate carboxylase subunit B; Catalyzes the formation of oxaloacetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.913 |
argA | AIN56794.1 | O165_022005 | O165_000130 | N-acetylglutamate synthase; Catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.810 |
argA | AIN57881.1 | O165_022005 | O165_006050 | N-acetylglutamate synthase; Catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | Adenylosuccinate lyase; Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.422 |
argA | argB | O165_022005 | O165_022600 | N-acetylglutamate synthase; Catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | 0.997 |
argA | argG | O165_022005 | O165_016925 | N-acetylglutamate synthase; Catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | Argininosuccinate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | 0.984 |
argA | argH | O165_022005 | O165_022425 | N-acetylglutamate synthase; Catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | Argininosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.993 |
argA | argJ | O165_022005 | O165_028650 | N-acetylglutamate synthase; Catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ornithine acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. | 0.998 |
argA | gltA | O165_022005 | O165_014750 | N-acetylglutamate synthase; Catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | Type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. | 0.447 |
argA | sdhB | O165_022005 | O165_014730 | N-acetylglutamate synthase; Catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | Part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.508 |
argA | speA | O165_022005 | O165_019375 | N-acetylglutamate synthase; Catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. | 0.577 |
argB | argA | O165_022600 | O165_022005 | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | N-acetylglutamate synthase; Catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.997 |
argB | argG | O165_022600 | O165_016925 | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | Argininosuccinate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | 0.967 |