node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKU94625.1 | AKV00930.1 | AKJ09_01289 | AKJ09_07593 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 5,10-methylenetetrahydrofolate reductase. | 0.924 |
AKU94625.1 | AKV02453.1 | AKJ09_01289 | AKJ09_09116 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.906 |
AKU94625.1 | AKV02454.1 | AKJ09_01289 | AKJ09_09117 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.900 |
AKU94625.1 | fhs | AKJ09_01289 | AKJ09_02730 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.920 |
AKU94625.1 | gcvT | AKJ09_01289 | AKJ09_06129 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Aminomethyltransferase (glycine cleavage system T protein); The glycine cleavage system catalyzes the degradation of glycine. | 0.908 |
AKU94625.1 | glyA | AKJ09_01289 | AKJ09_05921 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.926 |
AKU94625.1 | purH | AKJ09_01289 | AKJ09_09740 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | IMP cyclohydrolase. | 0.917 |
AKU94625.1 | purN | AKJ09_01289 | AKJ09_09986 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.911 |
AKV00930.1 | AKU94625.1 | AKJ09_07593 | AKJ09_01289 | 5,10-methylenetetrahydrofolate reductase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.924 |
AKV00930.1 | AKV02453.1 | AKJ09_07593 | AKJ09_09116 | 5,10-methylenetetrahydrofolate reductase. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.975 |
AKV00930.1 | AKV02454.1 | AKJ09_07593 | AKJ09_09117 | 5,10-methylenetetrahydrofolate reductase. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.999 |
AKV00930.1 | fhs | AKJ09_07593 | AKJ09_02730 | 5,10-methylenetetrahydrofolate reductase. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.955 |
AKV00930.1 | folD | AKJ09_07593 | AKJ09_08646 | 5,10-methylenetetrahydrofolate reductase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.948 |
AKV00930.1 | gcvT | AKJ09_07593 | AKJ09_06129 | 5,10-methylenetetrahydrofolate reductase. | Aminomethyltransferase (glycine cleavage system T protein); The glycine cleavage system catalyzes the degradation of glycine. | 0.955 |
AKV00930.1 | glyA | AKJ09_07593 | AKJ09_05921 | 5,10-methylenetetrahydrofolate reductase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.961 |
AKV00930.1 | purC | AKJ09_07593 | AKJ09_03586 | 5,10-methylenetetrahydrofolate reductase. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. | 0.420 |
AKV00930.1 | purH | AKJ09_07593 | AKJ09_09740 | 5,10-methylenetetrahydrofolate reductase. | IMP cyclohydrolase. | 0.947 |
AKV00930.1 | purN | AKJ09_07593 | AKJ09_09986 | 5,10-methylenetetrahydrofolate reductase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.945 |
AKV02453.1 | AKU94625.1 | AKJ09_09116 | AKJ09_01289 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.906 |
AKV02453.1 | AKV00930.1 | AKJ09_09116 | AKJ09_07593 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 5,10-methylenetetrahydrofolate reductase. | 0.975 |