AKV01399.1 protein (Labilithrix luteola) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Score

AKV01399.1

Two-component sensor histidine kinase. (688 aa)

Predicted Functional Partners:

AKV02844.1

0.985

AKU93828.1

0.984

AKV04521.1

0.977

AKV00713.1

0.975

AKV00729.1

0.960

AKU97562.1

0.956

AKV00518.1

0.950

AKU99936.1

0.945

AKU99937.1

0.933

AKU99609.1

0.928

Your Current Organism:

Labilithrix luteola

NCBI taxonomy Id: 1391654
Other names: DSM 27648, L. luteola, Labilithrix luteola Yamamoto et al. 2014, NBRC 109946, Sorangiineae bacterium B00002, strain B00002

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKU93828.1	AKU97562.1	AKJ09_00492	AKJ09_04226	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	Sensory box histidine kinase/response regulator.	0.987
AKU93828.1	AKU99609.1	AKJ09_00492	AKJ09_06273	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	Sensory box histidine kinase/response regulator.	0.982
AKU93828.1	AKU99936.1	AKJ09_00492	AKJ09_06600	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	Putative SigmaB asociated two-component system sensor protein.	0.993
AKU93828.1	AKU99937.1	AKJ09_00492	AKJ09_06601	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	Two-component sensor histidine kinase.	0.987
AKU93828.1	AKV00518.1	AKJ09_00492	AKJ09_07181	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	PAS family protein.	0.985
AKU93828.1	AKV00713.1	AKJ09_00492	AKJ09_07376	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	Two-component hybrid sensor and regulator.	0.990
AKU93828.1	AKV00729.1	AKJ09_00492	AKJ09_07392	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	Histidine kinase.	0.988
AKU93828.1	AKV01399.1	AKJ09_00492	AKJ09_08062	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	Two-component sensor histidine kinase.	0.984
AKU93828.1	AKV02844.1	AKJ09_00492	AKJ09_09507	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	Putative SigmaB asociated two-component system sensor protein.	0.993
AKU93828.1	AKV04521.1	AKJ09_00492	AKJ09_11184	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	Chemotaxis protein methyltransferase CheR.	0.993
AKU97562.1	AKU93828.1	AKJ09_04226	AKJ09_00492	Sensory box histidine kinase/response regulator.	Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s).	0.987
AKU97562.1	AKU99609.1	AKJ09_04226	AKJ09_06273	Sensory box histidine kinase/response regulator.	Sensory box histidine kinase/response regulator.	0.980
AKU97562.1	AKU99936.1	AKJ09_04226	AKJ09_06600	Sensory box histidine kinase/response regulator.	Putative SigmaB asociated two-component system sensor protein.	0.984
AKU97562.1	AKU99937.1	AKJ09_04226	AKJ09_06601	Sensory box histidine kinase/response regulator.	Two-component sensor histidine kinase.	0.978
AKU97562.1	AKV00518.1	AKJ09_04226	AKJ09_07181	Sensory box histidine kinase/response regulator.	PAS family protein.	0.981
AKU97562.1	AKV00713.1	AKJ09_04226	AKJ09_07376	Sensory box histidine kinase/response regulator.	Two-component hybrid sensor and regulator.	0.982
AKU97562.1	AKV00729.1	AKJ09_04226	AKJ09_07392	Sensory box histidine kinase/response regulator.	Histidine kinase.	0.973
AKU97562.1	AKV01399.1	AKJ09_04226	AKJ09_08062	Sensory box histidine kinase/response regulator.	Two-component sensor histidine kinase.	0.956
AKU97562.1	AKV02844.1	AKJ09_04226	AKJ09_09507	Sensory box histidine kinase/response regulator.	Putative SigmaB asociated two-component system sensor protein.	0.987
AKU97562.1	AKV04521.1	AKJ09_04226	AKJ09_11184	Sensory box histidine kinase/response regulator.	Chemotaxis protein methyltransferase CheR.	0.982

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.894

expected number of edges:

11

PPI enrichment p-value:

1.31e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015986

Proton motive force-driven ATP synthesis

3 of 15

1.85

1.39

0.0015

GO:0098662

Inorganic cation transmembrane transport

4 of 43

1.52

1.23

0.0015

GO:0009152

Purine ribonucleotide biosynthetic process

4 of 44

1.51

1.23

0.0015

GO:0006812

Cation transport

6 of 151

1.15

1.04

0.00052

GO:0034654

Nucleobase-containing compound biosynthetic process

5 of 227

0.89

0.63

0.0073

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022890

Inorganic cation transmembrane transporter activity

5 of 43

1.62

1.77

5.93e-05

GO:0019829

ATPase-coupled cation transmembrane transporter activity

3 of 10

2.03

1.65

0.00057

GO:0008289

Lipid binding

2 of 3

2.37

1.3

0.0040

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

3 of 19

1.75

1.26

0.0025

GO:0032553

Ribonucleotide binding

5 of 322

0.74

0.43

0.0402

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045259

Proton-transporting ATP synthase complex

3 of 13

1.91

1.48

0.0011

GO:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

2 of 6

2.07

1.11

0.0077

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3654

Mixed, incl. Heavy metal-associated domain superfamily, and Calcium ion transport

5 of 12

2.17

3.17

3.12e-07

CL:1141

ATP biosynthetic process

3 of 17

1.8

1.27

0.0026

CL:3657

Heavy metal-associated domain superfamily

2 of 5

2.15

0.93

0.0182

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

4 of 81

1.24

0.85

0.0074

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045259

Proton-transporting ATP synthase complex

3 of 18

1.77

1.1

0.0060

GOCC:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

2 of 9

1.9

0.76

0.0366

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0375

Hydrogen ion transport

3 of 11

1.99

1.5

0.0011

KW-0066

ATP synthesis

3 of 11

1.99

1.5

0.0011

KW-0446

Lipid-binding

2 of 2

2.55

1.47

0.0020

KW-0138

CF(0)

2 of 6

2.07

1.13

0.0073

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00137

ATP synthase subunit C

2 of 2

2.55

0.91

0.0223

PF00403

Heavy-metal-associated domain

2 of 4

2.25

0.84

0.0278

PF00122

E1-E2 ATPase

2 of 4

2.25

0.84

0.0278

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