AKV02000.1 protein (Labilithrix luteola) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Coexpression

Experiments

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[Homology]

Score

AKV02000.1

Hypothetical protein. (828 aa)

Predicted Functional Partners:

AKV03846.1

0.775

AKV00408.1

0.774

AKU95532.1

0.773

AKU97672.1

0.771

AKU99240.1

0.770

AKV03463.1

0.769

AKU94399.1

0.768

AKU99237.1

0.764

AKV01308.1

0.764

AKV03129.1

0.763

Your Current Organism:

Labilithrix luteola

NCBI taxonomy Id: 1391654
Other names: DSM 27648, L. luteola, Labilithrix luteola Yamamoto et al. 2014, NBRC 109946, Sorangiineae bacterium B00002, strain B00002

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKU94399.1	AKU95532.1	AKJ09_01063	AKJ09_02196	Hypothetical protein.	Tryptophan synthase alpha chain.	0.676
AKU94399.1	AKU97672.1	AKJ09_01063	AKJ09_04336	Hypothetical protein.	Hypothetical protein.	0.418
AKU94399.1	AKU99237.1	AKJ09_01063	AKJ09_05901	Hypothetical protein.	Membrane protein involved in the export of O-antigen, teichoic acid lipoteichoic acid.	0.635
AKU94399.1	AKU99240.1	AKJ09_01063	AKJ09_05904	Hypothetical protein.	Hypothetical protein.	0.723
AKU94399.1	AKV00408.1	AKJ09_01063	AKJ09_07071	Hypothetical protein.	Hypothetical protein.	0.773
AKU94399.1	AKV02000.1	AKJ09_01063	AKJ09_08663	Hypothetical protein.	Hypothetical protein.	0.768
AKU94399.1	AKV03129.1	AKJ09_01063	AKJ09_09792	Hypothetical protein.	Fatty acid desaturase family protein.	0.691
AKU94399.1	AKV03463.1	AKJ09_01063	AKJ09_10126	Hypothetical protein.	Surface antigen protein.	0.613
AKU94399.1	AKV03846.1	AKJ09_01063	AKJ09_10509	Hypothetical protein.	Fatty acid desaturase family protein.	0.757
AKU95532.1	AKU94399.1	AKJ09_02196	AKJ09_01063	Tryptophan synthase alpha chain.	Hypothetical protein.	0.676
AKU95532.1	AKU97672.1	AKJ09_02196	AKJ09_04336	Tryptophan synthase alpha chain.	Hypothetical protein.	0.730
AKU95532.1	AKU99237.1	AKJ09_02196	AKJ09_05901	Tryptophan synthase alpha chain.	Membrane protein involved in the export of O-antigen, teichoic acid lipoteichoic acid.	0.697
AKU95532.1	AKU99240.1	AKJ09_02196	AKJ09_05904	Tryptophan synthase alpha chain.	Hypothetical protein.	0.611
AKU95532.1	AKV01308.1	AKJ09_02196	AKJ09_07971	Tryptophan synthase alpha chain.	Chaperone protein DnaK.	0.723
AKU95532.1	AKV02000.1	AKJ09_02196	AKJ09_08663	Tryptophan synthase alpha chain.	Hypothetical protein.	0.773
AKU95532.1	AKV03129.1	AKJ09_02196	AKJ09_09792	Tryptophan synthase alpha chain.	Fatty acid desaturase family protein.	0.636
AKU95532.1	AKV03463.1	AKJ09_02196	AKJ09_10126	Tryptophan synthase alpha chain.	Surface antigen protein.	0.763
AKU95532.1	AKV03846.1	AKJ09_02196	AKJ09_10509	Tryptophan synthase alpha chain.	Fatty acid desaturase family protein.	0.747
AKU97672.1	AKU94399.1	AKJ09_04336	AKJ09_01063	Hypothetical protein.	Hypothetical protein.	0.418
AKU97672.1	AKU95532.1	AKJ09_04336	AKJ09_02196	Hypothetical protein.	Tryptophan synthase alpha chain.	0.730

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009097

Isoleucine biosynthetic process

7 of 14

2.26

5.34

2.79e-12

GO:0009099

Valine biosynthetic process

5 of 10

2.26

3.86

1.31e-08

GO:1901607

Alpha-amino acid biosynthetic process

10 of 104

1.55

3.16

1.07e-12

GO:0046394

Carboxylic acid biosynthetic process

11 of 166

1.39

2.55

1.07e-12

GO:0043650

Dicarboxylic acid biosynthetic process

3 of 19

1.76

1.4

0.0012

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000287

Magnesium ion binding

5 of 65

1.45

1.34

0.00046

GO:0019842

Vitamin binding

4 of 46

1.5

1.14

0.0026

GO:0015930

Glutamate synthase activity

2 of 2

2.56

1.12

0.0090

GO:0004455

Ketol-acid reductoisomerase activity

2 of 2

2.56

1.12

0.0090

GO:0050661

NADP binding

3 of 22

1.7

1.01

0.0090

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005948

Acetolactate synthase complex

2 of 2

2.56

1.39

0.0028

GO:0005829

Cytosol

7 of 324

0.9

0.76

0.00080

GO:0005737

Cytoplasm

9 of 1245

0.42

0.29

0.0348

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:993

Branched-chain amino acid metabolic process

6 of 23

1.98

3.5

1.00e-08

CL:924

Branched-chain amino acid metabolic process, and Aspartate family amino acid biosynthetic process

8 of 58

1.7

3.32

2.20e-10

CL:923

Alpha-amino acid biosynthetic process, and Dicarboxylic acid metabolic process

9 of 84

1.59

3.09

5.47e-11

CL:996

Branched-chain amino acid metabolic process

4 of 17

1.94

2.12

3.68e-05

CL:810

Glutamate biosynthetic process, and Ammonia ligase activity

2 of 5

2.17

0.87

0.0239

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00290

Valine, leucine and isoleucine biosynthesis

7 of 22

2.07

4.63

1.56e-11

map00770

Pantothenate and CoA biosynthesis

6 of 21

2.02

3.94

8.68e-10

map01210

2-Oxocarboxylic acid metabolism

6 of 51

1.63

2.58

7.73e-08

map01230

Biosynthesis of amino acids

10 of 159

1.36

2.38

1.56e-11

map00660

C5-Branched dibasic acid metabolism

2 of 10

1.87

1.09

0.0074

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005948

Acetolactate synthase complex

2 of 4

2.26

1.07

0.0102

GOCC:0005737

Cytoplasm

10 of 946

0.59

0.47

0.0014

GOCC:0005622

Intracellular

11 of 1345

0.48

0.39

0.0014

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0100

Branched-chain amino acid biosynthesis

4 of 14

2.02

2.3

1.87e-05

KW-0412

Isoleucine biosynthesis

2 of 3

2.39

1.26

0.0047

KW-0663

Pyridoxal phosphate

3 of 40

1.44

0.92

0.0091

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04898

Glutamate synthase central domain

2 of 2

2.56

0.85

0.0286

PF02776

Thiamine pyrophosphate enzyme, N-terminal TPP binding domain

2 of 2

2.56

0.85

0.0286

PF01645

Conserved region in glutamate synthase

2 of 2

2.56

0.85

0.0286

PF01493

GXGXG motif

2 of 2

2.56

0.85

0.0286

PF01450

Acetohydroxy acid isomeroreductase, catalytic domain

2 of 2

2.56

0.85

0.0286

(more ...)

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