AKV03724.1 protein (Labilithrix luteola) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

AKV03724.1

Phosphoenolpyruvate phosphomutase. (552 aa)

Predicted Functional Partners:

AKV03725.1

0.996

phnW

0.952

AKV03727.1

0.834

AKV03728.1

0.820

AKU94832.1

0.805

AKV02990.1

0.765

AKU96624.1

0.752

AKU96420.1

0.706

AKU98439.1

0.694

mdh

0.684

Your Current Organism:

Labilithrix luteola

NCBI taxonomy Id: 1391654
Other names: DSM 27648, L. luteola, Labilithrix luteola Yamamoto et al. 2014, NBRC 109946, Sorangiineae bacterium B00002, strain B00002

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKU94832.1	AKU98439.1	AKJ09_01496	AKJ09_05103	Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family.	Hypothetical protein.	0.466
AKU94832.1	AKV03724.1	AKJ09_01496	AKJ09_10387	Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family.	Phosphoenolpyruvate phosphomutase.	0.805
AKU96420.1	AKV02990.1	AKJ09_03084	AKJ09_09653	Citrate synthase (si); Belongs to the citrate synthase family.	Citrate synthase (si).	0.932
AKU96420.1	AKV03724.1	AKJ09_03084	AKJ09_10387	Citrate synthase (si); Belongs to the citrate synthase family.	Phosphoenolpyruvate phosphomutase.	0.706
AKU96420.1	mdh	AKJ09_03084	AKJ09_10386	Citrate synthase (si); Belongs to the citrate synthase family.	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.	0.973
AKU96624.1	AKV02990.1	AKJ09_03288	AKJ09_09653	Oxidoreductase, short chain dehydrogenase/reductase family.	Citrate synthase (si).	0.497
AKU96624.1	AKV03724.1	AKJ09_03288	AKJ09_10387	Oxidoreductase, short chain dehydrogenase/reductase family.	Phosphoenolpyruvate phosphomutase.	0.752
AKU96624.1	mdh	AKJ09_03288	AKJ09_10386	Oxidoreductase, short chain dehydrogenase/reductase family.	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.	0.452
AKU96624.1	phnW	AKJ09_03288	AKJ09_10389	Oxidoreductase, short chain dehydrogenase/reductase family.	2-aminoethylphosphonate:pyruvate aminotransferase; Involved in phosphonate degradation; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.	0.450
AKU98439.1	AKU94832.1	AKJ09_05103	AKJ09_01496	Hypothetical protein.	Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family.	0.466
AKU98439.1	AKV03724.1	AKJ09_05103	AKJ09_10387	Hypothetical protein.	Phosphoenolpyruvate phosphomutase.	0.694
AKV02990.1	AKU96420.1	AKJ09_09653	AKJ09_03084	Citrate synthase (si).	Citrate synthase (si); Belongs to the citrate synthase family.	0.932
AKV02990.1	AKU96624.1	AKJ09_09653	AKJ09_03288	Citrate synthase (si).	Oxidoreductase, short chain dehydrogenase/reductase family.	0.497
AKV02990.1	AKV03724.1	AKJ09_09653	AKJ09_10387	Citrate synthase (si).	Phosphoenolpyruvate phosphomutase.	0.765
AKV02990.1	mdh	AKJ09_09653	AKJ09_10386	Citrate synthase (si).	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.	0.982
AKV03724.1	AKU94832.1	AKJ09_10387	AKJ09_01496	Phosphoenolpyruvate phosphomutase.	Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family.	0.805
AKV03724.1	AKU96420.1	AKJ09_10387	AKJ09_03084	Phosphoenolpyruvate phosphomutase.	Citrate synthase (si); Belongs to the citrate synthase family.	0.706
AKV03724.1	AKU96624.1	AKJ09_10387	AKJ09_03288	Phosphoenolpyruvate phosphomutase.	Oxidoreductase, short chain dehydrogenase/reductase family.	0.752
AKV03724.1	AKU98439.1	AKJ09_10387	AKJ09_05103	Phosphoenolpyruvate phosphomutase.	Hypothetical protein.	0.694
AKV03724.1	AKV02990.1	AKJ09_10387	AKJ09_09653	Phosphoenolpyruvate phosphomutase.	Citrate synthase (si).	0.765

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Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.728

expected number of edges:

13

PPI enrichment p-value:

0.00398

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006811

Ion transport

7 of 67

1.54

2.24

3.35e-07

GO:0055072

Iron ion homeostasis

2 of 5

2.12

0.93

0.0180

GO:0098662

Inorganic cation transmembrane transport

3 of 33

1.48

0.84

0.0160

GO:0065007

Biological regulation

8 of 482

0.74

0.55

0.0039

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046915

Transition metal ion transmembrane transporter activity

3 of 8

2.1

1.57

0.00093

GO:0046914

Transition metal ion binding

6 of 87

1.36

1.48

5.35e-05

GO:0015093

Ferrous iron transmembrane transporter activity

2 of 2

2.52

1.21

0.0060

GO:0046872

Metal ion binding

7 of 381

0.79

0.57

0.0060

GO:0043167

Ion binding

9 of 779

0.58

0.43

0.0060

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2881

Mixed, incl. Ferrous iron transporter FeoA domain, and Phosphoglycerate mutase family

4 of 12

2.04

2.07

6.66e-05

CL:6577

Mixed, incl. Iron transport, and Ferrous iron transporter FeoA domain

2 of 6

2.04

0.71

0.0483

CL:2883

Ferrous iron transporter FeoA domain, and Iron transport

2 of 5

2.12

0.71

0.0483

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0410

Iron transport

2 of 2

2.52

1.12

0.0089

KW-0408

Iron

3 of 45

1.35

0.7

0.0292

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07670

Nucleoside recognition

3 of 3

2.52

2.0

0.00019

PF07664

Ferrous iron transport protein B C terminus

3 of 3

2.52

2.0

0.00019

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030389

FeoB-type guanine nucleotide-binding (G) domain

3 of 3

2.52

1.8

0.00046

IPR011642

Nucleoside transporter/FeoB GTPase, Gate domain

3 of 3

2.52

1.8

0.00046

IPR011640

Ferrous iron transport protein B, C-terminal

3 of 3

2.52

1.8

0.00046

IPR038157

Ferrous iron transporter, core domain

3 of 4

2.4

1.78

0.00046

IPR007167

Ferrous iron transporter FeoA domain

3 of 4

2.4

1.78

0.00046

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00899

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria. This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble ...

3 of 4

2.4

2.19

7.40e-05

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