STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KCZ72092.1DNA polymerase IV (family X); PFAM: PHP domain; DNA polymerase beta thumb; Helix-hairpin-helix domain. (569 aa)    
Predicted Functional Partners:
fen
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]
   
 0.928
lig
ATP-dependent DNA ligase I; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
  
 0.926
KCZ72645.1
PFAM: DNA polymerase Ligase (LigD); TIGRFAM: DNA ligase D, 3'-phosphoesterase domain.
  
 0.925
pcn
DNA polymerase sliding clamp subunit; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
    
 0.830
mutS
Mismatch repair ATPase (MutS family); Has ATPase and non-specific DNA-binding activities. Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
 
  
 0.618
KCZ71489.1
Superfamily II helicase; PFAM: Protein of unknown function DUF91; Helicase conserved C-terminal domain; Sec63 Brl domain; DEAD/DEAH box helicase.
   
 
 0.605
ruvA
Holliday junction DNA helicase subunit RuvA; PFAM: RuvA, C-terminal domain; RuvA N terminal domain; Helix-hairpin-helix domain; TIGRFAM: Holliday junction DNA helicase, RuvA subunit.
    
 0.591
KCZ72116.1
DNA polymerase elongation subunit (family B); PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain.
   
 0.571
KCZ72380.1
Putative exonuclease of the beta-lactamase fold involved in RNA processing; PFAM: Beta-lactamase superfamily domain.
    
 0.554
KCZ70654.1
Putative exonuclease of the beta-lactamase fold involved in RNA processing; PFAM: Beta-lactamase superfamily domain; RNA-metabolising metallo-beta-lactamase; Beta-Casp domain.
    
 0.554
Your Current Organism:
Methanoperedens nitroreducens
NCBI taxonomy Id: 1392998
Other names: C. Methanoperedens nitroreducens, Candidatus Methanoperedens nitroreducens
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