STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A371D1L7Dna2-domain-containing protein. (1178 aa)    
Predicted Functional Partners:
A0A371CZ16
Ribonuclease H-like protein.
   
 0.995
A0A371DUQ7
Ribonuclease H-like protein.
   
 0.995
A0A371CX59
WD_REPEATS_REGION domain-containing protein.
   
 
 0.984
A0A371CS78
PIN domain-like protein.
   
 0.976
A0A371DV80
Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.
    
 0.974
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
   
 0.973
A0A371DV74
Uncharacterized protein.
    
 0.969
A0A371CNK9
Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
   
 0.937
A0A371CYS3
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
   
 0.935
A0A371DT82
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
   
 0.935
Your Current Organism:
Polyporus brumalis
NCBI taxonomy Id: 139420
Other names: P. brumalis
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