Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LepBHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (174 aa)    
Predicted Functional Partners:
lepA
Elongation factor 4; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.
 
 
 0.920
lepB-2
Signal peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S26 family.
 
  
0.920
lepB
Signal peptidase I; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S26 family.
 
  
0.919
secDF
Preprotein translocase subunit SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily.
  
  
 0.798
KLV26316.1
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.796
KLV27857.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.767
tuf
Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.
   
  
 0.761
KLV28290.1
Ribonuclease H; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.739
KLV26704.1
Cytoplasmic protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
    0.716
mntR
Manganese transport transcriptional regulator; Central regulator of manganese homeostasis. Belongs to the DtxR/MntR family.
   
    0.712
Your Current Organism:
Bacillus circulans
NCBI taxonomy Id: 1397
Other names: ATCC 24, ATCC 4513, ATCC 9140, B. circulans, BCRC 10605, Bacillus sp. 3399BRRJ, Bacillus sp. NCIM 2107, Bacillus sp. NCIM 5045, Bacillus sp. NCIM 5046, CCM 2048, CCRC 10605, CCRC:10605, CCUG 7416, CIP 52.75, DSM 11, IAM 12462, IFO 13626, JCM 2504, LMG 13261, LMG 6926, LMG:13261, LMG:6926, NBRC 13626, NCCB 75011, NCIB 9374, NCIMB 9374, NCTC 2610, NRRL B-378, NRRL B-380
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