STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KLV24475.12-isopropylmalate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (511 aa)    
Predicted Functional Partners:
leuC
Isopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.997
leuD
Isopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.997
ilvD
Dihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family.
 
 
 0.994
ilvN
Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.993
ilvB
Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.992
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.987
LeuB
3-isopropylmalate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.987
KLV25092.1
Branched-chain amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.973
KLV23859.1
Acetaldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
  
 0.949
acsA
acetyl-CoA synthetase; Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.933
Your Current Organism:
Bacillus circulans
NCBI taxonomy Id: 1397
Other names: ATCC 24, ATCC 4513, ATCC 9140, B. circulans, BCRC 10605, Bacillus sp. 3399BRRJ, Bacillus sp. NCIM 2107, Bacillus sp. NCIM 5045, Bacillus sp. NCIM 5046, CCM 2048, CCRC 10605, CCRC:10605, CCUG 7416, CIP 52.75, DSM 11, IAM 12462, IFO 13626, JCM 2504, LMG 13261, LMG 6926, LMG:13261, LMG:6926, NBRC 13626, NCCB 75011, NCIB 9374, NCIMB 9374, NCTC 2610, NRRL B-378, NRRL B-380
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