STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A182LZ48Uncharacterized protein. (1199 aa)    
Predicted Functional Partners:
A0A182LW56
Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
   
 0.961
A0A182MLG4
ATP_bind_3 domain-containing protein.
 
     0.902
A0A182MWX2
Uncharacterized protein.
    
  0.761
A0A182M1F8
Uncharacterized protein.
  
 
 0.712
A0A182MLN1
Uncharacterized protein.
  
 
 0.693
A0A182M1E2
Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...]
  
 
 0.688
A0A182MWH9
Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
    
 0.666
A0A182LWN9
MGS domain-containing protein.
   
  0.663
A0A182MAU6
Uncharacterized protein.
    
  0.663
A0A182MEE8
Glucose-6-phosphate isomerase; Belongs to the GPI family.
    
  0.663
Your Current Organism:
Anopheles culicifacies
NCBI taxonomy Id: 139723
Other names: A. culicifacies
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