ETY74003.1 protein (Lactobacillus fabifermentans)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

ETY74003.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (369 aa)

Predicted Functional Partners:

ETY73996.1

0.987

ETY72647.1

0.940

ETY73197.1

0.937

ETY73993.1

0.872

ETY73994.1

0.869

ETY73995.1

0.787

ETY73997.1

0.773

ETY74494.1

0.585

ETY75280.1

0.550

ETY75687.1

0.482

Your Current Organism:

Lactobacillus fabifermentans

NCBI taxonomy Id: 1400520
Other names: L. fabifermentans T30PCM01, Lactobacillus fabifermentans T30PCM01

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ETY72647.1	ETY74003.1	LFAB_16485	LFAB_09460	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.940
ETY73197.1	ETY74003.1	LFAB_13835	LFAB_09460	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.937
ETY73993.1	ETY73994.1	LFAB_09445	LFAB_09450	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.952
ETY73993.1	ETY73995.1	LFAB_09445	LFAB_09455	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Antibiotic ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.959
ETY73993.1	ETY73996.1	LFAB_09445	LFAB_09465	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	LuxR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.741
ETY73993.1	ETY73997.1	LFAB_09445	LFAB_09470	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.534
ETY73993.1	ETY74003.1	LFAB_09445	LFAB_09460	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.872
ETY73994.1	ETY73993.1	LFAB_09450	LFAB_09445	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.952
ETY73994.1	ETY73995.1	LFAB_09450	LFAB_09455	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Antibiotic ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.948
ETY73994.1	ETY73996.1	LFAB_09450	LFAB_09465	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	LuxR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.721
ETY73994.1	ETY73997.1	LFAB_09450	LFAB_09470	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.534
ETY73994.1	ETY74003.1	LFAB_09450	LFAB_09460	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.869
ETY73995.1	ETY73993.1	LFAB_09455	LFAB_09445	Antibiotic ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.959
ETY73995.1	ETY73994.1	LFAB_09455	LFAB_09450	Antibiotic ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.948
ETY73995.1	ETY73996.1	LFAB_09455	LFAB_09465	Antibiotic ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	LuxR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.720
ETY73995.1	ETY73997.1	LFAB_09455	LFAB_09470	Antibiotic ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.539
ETY73995.1	ETY74003.1	LFAB_09455	LFAB_09460	Antibiotic ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.787
ETY73996.1	ETY73993.1	LFAB_09465	LFAB_09445	LuxR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.741
ETY73996.1	ETY73994.1	LFAB_09465	LFAB_09450	LuxR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.721
ETY73996.1	ETY73995.1	LFAB_09465	LFAB_09455	LuxR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Antibiotic ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.720

page 1 of 2

Network Stats

number of nodes:

5

number of edges:

9

average node degree:

3.6

avg. local clustering coefficient:

0.9

expected number of edges:

9

PPI enrichment p-value:

0.39

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006259

DNA metabolic process

6 of 123

1.23

1.1

0.00069

GO:0071103

DNA conformation change

3 of 25

1.62

0.98

0.0092

GO:0090305

Nucleic acid phosphodiester bond hydrolysis

4 of 61

1.36

0.94

0.0061

GO:0090304

Nucleic acid metabolic process

7 of 271

0.95

0.77

0.0017

GO:0006139

Nucleobase-containing compound metabolic process

8 of 441

0.8

0.63

0.0018

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140097

Catalytic activity, acting on DNA

6 of 74

1.45

1.69

2.18e-05

GO:0140657

ATP-dependent activity

6 of 120

1.24

1.27

0.00011

GO:0140640

Catalytic activity, acting on a nucleic acid

7 of 175

1.14

1.19

5.10e-05

GO:0004527

Exonuclease activity

3 of 22

1.68

1.07

0.0063

GO:0008094

ATP-dependent activity, acting on DNA

3 of 23

1.66

1.06

0.0063

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030894

Replisome

2 of 6

2.06

0.85

0.0255

GO:1990391

DNA repair complex

2 of 7

2.0

0.84

0.0255

GO:0043590

Bacterial nucleoid

2 of 16

1.64

0.78

0.0274

GO:0032991

Protein-containing complex

5 of 222

0.89

0.53

0.0255

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:594

Mixed, incl. Homologous recombination, and DNA repair complex

9 of 42

1.87

4.51

2.98e-13

CL:664

Mixed, incl. 5-3 exonuclease, and Helicase and RNase D C-terminal

5 of 5

2.54

4.4

3.00e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-168256

Immune System

3 of 36

1.46

1.08

0.0033

MAP-168249

Innate Immune System

2 of 30

1.37

0.66

0.0389

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0540

Nuclease

3 of 31

1.53

0.84

0.0177

KW-0347

Helicase

3 of 29

1.56

0.84

0.0177

KW-0269

Exonuclease

2 of 14

1.7

0.77

0.0311

KW-0235

DNA replication

2 of 16

1.64

0.76

0.0311

KW-0233

DNA recombination

2 of 15

1.67

0.76

0.0311

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036279

5-3 exonuclease, C-terminal domain superfamily

2 of 2

2.54

0.81

0.0345

IPR020046

5-3 exonuclease, alpha-helical arch, N-terminal

2 of 2

2.54

0.81

0.0345

IPR020045

DNA polymerase I-like, H3TH domain

2 of 2

2.54

0.81

0.0345

IPR008918

Helix-hairpin-helix motif, class 2

2 of 2

2.54

0.81

0.0345

IPR002421

5-3 exonuclease

2 of 2

2.54

0.81

0.0345

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00279

Helix-hairpin-helix class 2 (Pol1 family) motifs

2 of 2

2.54

1.24

0.0054

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