SHF97299.1 protein (Sulfitobacter pseudonitzschiae)

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

SHF97299.1

Chromate reductase. (180 aa)

Predicted Functional Partners:

yiaD-2

0.500

luxA

0.482

SHF90743.1

0.482

SHF81796.1

0.480

ada

0.473

SHF69299.1

0.472

yghU

0.437

yfcG-2

0.437

SHG33989.1

0.437

Your Current Organism:

Sulfitobacter pseudonitzschiae

NCBI taxonomy Id: 1402135
Other names: DSM 26824, MCCC 1A00686, S. pseudonitzschiae, Sulfitobacter pseudonitzschiae Hong et al. 2015, Sulfitobacter sp. H3, Sulfitobacter sp. MCCC 1A00686, strain H3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SHF69299.1	SHF97299.1	SAMN05444149_105118	SAMN05444149_107117	Predicted dithiol-disulfide isomerase, DsbA family.	Chromate reductase.	0.472
SHF81796.1	SHF97299.1	SAMN05444149_105536	SAMN05444149_107117	Predicted dithiol-disulfide isomerase, DsbA family.	Chromate reductase.	0.480
SHF90743.1	SHF97299.1	SAMN05444149_106162	SAMN05444149_107117	Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase).	Chromate reductase.	0.482
SHF97299.1	SHF69299.1	SAMN05444149_107117	SAMN05444149_105118	Chromate reductase.	Predicted dithiol-disulfide isomerase, DsbA family.	0.472
SHF97299.1	SHF81796.1	SAMN05444149_107117	SAMN05444149_105536	Chromate reductase.	Predicted dithiol-disulfide isomerase, DsbA family.	0.480
SHF97299.1	SHF90743.1	SAMN05444149_107117	SAMN05444149_106162	Chromate reductase.	Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase).	0.482
SHF97299.1	SHG33989.1	SAMN05444149_107117	SAMN05444149_1223	Chromate reductase.	Glutathione S-transferase.	0.437
SHF97299.1	ada	SAMN05444149_107117	SAMN05444149_107115	Chromate reductase.	Bifunctional transcriptional activator/DNA repair enzyme Ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase.	0.473
SHF97299.1	luxA	SAMN05444149_107117	SAMN05444149_102217	Chromate reductase.	Luciferase family oxidoreductase, group 1.	0.482
SHF97299.1	yfcG-2	SAMN05444149_107117	SAMN05444149_11342	Chromate reductase.	GST-like protein.	0.437
SHF97299.1	yghU	SAMN05444149_107117	SAMN05444149_104537	Chromate reductase.	GST-like protein.	0.437
SHF97299.1	yiaD-2	SAMN05444149_107117	SAMN05444149_107116	Chromate reductase.	Outer membrane protein OmpA.	0.500
SHG33989.1	SHF97299.1	SAMN05444149_1223	SAMN05444149_107117	Glutathione S-transferase.	Chromate reductase.	0.437
ada	SHF97299.1	SAMN05444149_107115	SAMN05444149_107117	Bifunctional transcriptional activator/DNA repair enzyme Ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase.	Chromate reductase.	0.473
ada	yiaD-2	SAMN05444149_107115	SAMN05444149_107116	Bifunctional transcriptional activator/DNA repair enzyme Ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase.	Outer membrane protein OmpA.	0.553
luxA	SHF97299.1	SAMN05444149_102217	SAMN05444149_107117	Luciferase family oxidoreductase, group 1.	Chromate reductase.	0.482
yfcG-2	SHF97299.1	SAMN05444149_11342	SAMN05444149_107117	GST-like protein.	Chromate reductase.	0.437
yghU	SHF97299.1	SAMN05444149_104537	SAMN05444149_107117	GST-like protein.	Chromate reductase.	0.437
yiaD-2	SHF97299.1	SAMN05444149_107116	SAMN05444149_107117	Outer membrane protein OmpA.	Chromate reductase.	0.500
yiaD-2	ada	SAMN05444149_107116	SAMN05444149_107115	Outer membrane protein OmpA.	Bifunctional transcriptional activator/DNA repair enzyme Ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase.	0.553

Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.526

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

6 of 143

1.2

1.18

0.00017

GO:0050896

Response to stimulus

9 of 320

1.03

1.14

2.79e-06

GO:0050794

Regulation of cellular process

10 of 417

0.96

1.05

1.33e-06

GO:0000160

Phosphorelay signal transduction system

4 of 80

1.28

0.9

0.0058

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016772

Transferase activity, transferring phosphorus-containing groups

5 of 171

1.04

0.58

0.0315

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

8 of 731

0.62

0.43

0.0116

GO:0016020

Membrane

9 of 1060

0.51

0.36

0.0116

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2286

His Kinase A (phosphoacceptor) domain, and PAS-associated, C-terminal

11 of 30

2.14

7.51

1.73e-20

CL:2287

His Kinase A (phosphoacceptor) domain, and PAS fold

9 of 25

2.13

6.36

1.89e-16

CL:2288

PAS-associated, C-terminal, and His Kinase A (phosphoacceptor) domain

6 of 18

2.1

4.22

3.75e-10

CL:2308

His Kinase A (phosphoacceptor) domain

3 of 8

2.15

2.05

9.45e-05

CL:2289

PAS-associated, C-terminal

3 of 10

2.05

1.91

0.00016

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

9 of 332

1.01

1.15

8.50e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045121

Membrane raft

2 of 4

2.28

1.06

0.0110

GOCC:0016020

Membrane

8 of 515

0.77

0.61

0.0016

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

9 of 62

1.74

3.97

4.21e-13

KW-0418

Kinase

10 of 88

1.63

3.66

7.67e-14

KW-0175

Coiled coil

7 of 416

0.8

0.65

0.0013

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005467

Histidine kinase domain

10 of 38

2.0

5.76

2.20e-16

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

9 of 31

2.04

5.6

4.75e-15

IPR003594

Histidine kinase/HSP90-like ATPase

10 of 46

1.91

5.28

5.97e-16

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

8 of 27

2.05

5.1

3.22e-13

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

10 of 54

1.84

4.87

1.69e-15

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

9 of 32

2.03

5.73

9.57e-16

SM00387

Histidine kinase-like ATPases

10 of 52

1.86

5.1

2.83e-16

SM00448

cheY-homologous receiver domain

9 of 53

1.81

4.45

3.66e-14

SM00091

PAS domain

5 of 38

1.7

2.39

1.06e-06

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

3 of 30

1.58

1.27

0.0015

(more ...)

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