| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARJ21140.1 | ARJ21141.1 | B7492_07755 | B7492_07760 | Histidinol-phosphatase; Catalyzes the formation of L-histidinol from L-histidinol phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PHP hydrolase family. HisK subfamily. | DUF4025 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.586 |
| ARJ21140.1 | hisA | B7492_07755 | B7492_07735 | Histidinol-phosphatase; Catalyzes the formation of L-histidinol from L-histidinol phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PHP hydrolase family. HisK subfamily. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.801 |
| ARJ21140.1 | hisB | B7492_07755 | B7492_07725 | Histidinol-phosphatase; Catalyzes the formation of L-histidinol from L-histidinol phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PHP hydrolase family. HisK subfamily. | Imidazoleglycerol-phosphate dehydratase; Catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.921 |
| ARJ21140.1 | hisD | B7492_07755 | B7492_07720 | Histidinol-phosphatase; Catalyzes the formation of L-histidinol from L-histidinol phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PHP hydrolase family. HisK subfamily. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.983 |
| ARJ21140.1 | hisE | B7492_07755 | B7492_07750 | Histidinol-phosphatase; Catalyzes the formation of L-histidinol from L-histidinol phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PHP hydrolase family. HisK subfamily. | phosphoribosyl-ATP diphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.819 |
| ARJ21140.1 | hisF | B7492_07755 | B7492_07740 | Histidinol-phosphatase; Catalyzes the formation of L-histidinol from L-histidinol phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PHP hydrolase family. HisK subfamily. | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.821 |
| ARJ21140.1 | hisG | B7492_07755 | B7492_07715 | Histidinol-phosphatase; Catalyzes the formation of L-histidinol from L-histidinol phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PHP hydrolase family. HisK subfamily. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.803 |
| ARJ21140.1 | hisH | B7492_07755 | B7492_07730 | Histidinol-phosphatase; Catalyzes the formation of L-histidinol from L-histidinol phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PHP hydrolase family. HisK subfamily. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.880 |
| ARJ21140.1 | hisI | B7492_07755 | B7492_07745 | Histidinol-phosphatase; Catalyzes the formation of L-histidinol from L-histidinol phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PHP hydrolase family. HisK subfamily. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.936 |
| ARJ21140.1 | hisZ | B7492_07755 | B7492_07710 | Histidinol-phosphatase; Catalyzes the formation of L-histidinol from L-histidinol phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PHP hydrolase family. HisK subfamily. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.753 |
| ARJ21141.1 | ARJ21140.1 | B7492_07760 | B7492_07755 | DUF4025 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Histidinol-phosphatase; Catalyzes the formation of L-histidinol from L-histidinol phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PHP hydrolase family. HisK subfamily. | 0.586 |
| ARJ21141.1 | hisA | B7492_07760 | B7492_07735 | DUF4025 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.546 |
| ARJ21141.1 | hisB | B7492_07760 | B7492_07725 | DUF4025 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Imidazoleglycerol-phosphate dehydratase; Catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.567 |
| ARJ21141.1 | hisD | B7492_07760 | B7492_07720 | DUF4025 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.559 |
| ARJ21141.1 | hisE | B7492_07760 | B7492_07750 | DUF4025 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | phosphoribosyl-ATP diphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.558 |
| ARJ21141.1 | hisF | B7492_07760 | B7492_07740 | DUF4025 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.546 |
| ARJ21141.1 | hisG | B7492_07760 | B7492_07715 | DUF4025 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.530 |
| ARJ21141.1 | hisH | B7492_07760 | B7492_07730 | DUF4025 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.567 |
| ARJ21141.1 | hisI | B7492_07760 | B7492_07745 | DUF4025 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.558 |
| ARJ21141.1 | hisZ | B7492_07760 | B7492_07710 | DUF4025 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.530 |