fhuG5 protein (Paenibacillus polymyxa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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Experiments

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[Homology]

Score

fhuG5

Iron ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (348 aa)

Predicted Functional Partners:

fecE

0.898

fhuC1

0.881

fhuC3

0.877

fepC

0.863

fecE-2

0.862

fhuB9

0.837

AIY07223.1

0.808

yxeB11

0.807

fhuD9

0.762

yvrC

0.761

Your Current Organism:

Paenibacillus polymyxa

NCBI taxonomy Id: 1406
Other names: ATCC 842, Aerobacillus polymyxa, Bacillus polymyxa, Bacillus sp. NCIM 2538, Bacillus sp. NCIM 2540, Bacillus sp. NCIM 2726, Bacillus sp. RP 2.2, CCUG 7426, CFBP 4258, CIP 66.22, Clostridium polymyxa, DSM 36, Granulobacter polymyxa, HAMBI 635, IAM 13419, IFO 15309, JCM 2507, LMG 13294, LMG:13294, NBRC 15309, NCCB 24016, NCIB 8158, NCIB:8158, NCTC 10343, NRRL B-4317, P. polymyxa, Paenibacillus sp. JCM 8035, Paenibacillus sp. JCM 8036, Paenibacillus sp. JCM 8037, Paenibacillus sp. JCM 8038, Paenibacillus sp. JCM 8039, Paenibacillus sp. WLY78, VKM B-514

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIY07223.1	fecE	LK13_00970	LK13_10985	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Iron-dicitrate transporter ATP-binding subunit; Part of the FecBCDE citrate-dependent iron (III) transport system; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.880
AIY07223.1	fecE-2	LK13_00970	LK13_23555	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.504
AIY07223.1	fepC	LK13_00970	LK13_19610	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.595
AIY07223.1	fhuB9	LK13_00970	LK13_00965	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Ferrichrome ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.803
AIY07223.1	fhuC1	LK13_00970	LK13_08520	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Iron ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.819
AIY07223.1	fhuC3	LK13_00970	LK13_08565	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.843
AIY07223.1	fhuG5	LK13_00970	LK13_00960	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Iron ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.808
AIY07223.1	yxeB11	LK13_00970	LK13_00980	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Fe3+-hydroxamate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.652
fecE	AIY07223.1	LK13_10985	LK13_00970	Iron-dicitrate transporter ATP-binding subunit; Part of the FecBCDE citrate-dependent iron (III) transport system; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.880
fecE	fhuB9	LK13_10985	LK13_00965	Iron-dicitrate transporter ATP-binding subunit; Part of the FecBCDE citrate-dependent iron (III) transport system; Derived by automated computational analysis using gene prediction method: Protein Homology.	Ferrichrome ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.896
fecE	fhuD9	LK13_10985	LK13_05505	Iron-dicitrate transporter ATP-binding subunit; Part of the FecBCDE citrate-dependent iron (III) transport system; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.891
fecE	fhuG5	LK13_10985	LK13_00960	Iron-dicitrate transporter ATP-binding subunit; Part of the FecBCDE citrate-dependent iron (III) transport system; Derived by automated computational analysis using gene prediction method: Protein Homology.	Iron ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.898
fecE	yvrC	LK13_10985	LK13_19600	Iron-dicitrate transporter ATP-binding subunit; Part of the FecBCDE citrate-dependent iron (III) transport system; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.508
fecE	yxeB11	LK13_10985	LK13_00980	Iron-dicitrate transporter ATP-binding subunit; Part of the FecBCDE citrate-dependent iron (III) transport system; Derived by automated computational analysis using gene prediction method: Protein Homology.	Fe3+-hydroxamate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.888
fecE-2	AIY07223.1	LK13_23555	LK13_00970	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.504
fecE-2	fhuB9	LK13_23555	LK13_00965	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Ferrichrome ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.872
fecE-2	fhuD9	LK13_23555	LK13_05505	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.551
fecE-2	fhuG5	LK13_23555	LK13_00960	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Iron ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.	0.862
fecE-2	yvrC	LK13_23555	LK13_19600	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.800
fecE-2	yxeB11	LK13_23555	LK13_00980	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Fe3+-hydroxamate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.504

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015979

Photosynthesis

11 of 117

1.66

4.0

1.23e-15

GO:0019684

Photosynthesis, light reaction

6 of 40

1.86

3.0

7.95e-08

GO:0009767

Photosynthetic electron transport chain

3 of 16

1.96

1.38

0.0019

GO:0042549

Photosystem II stabilization

2 of 3

2.51

1.16

0.0076

GO:0009772

Photosynthetic electron transport in photosystem II

2 of 8

2.08

0.93

0.0178

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046906

Tetrapyrrole binding

4 of 58

1.52

1.1

0.0036

GO:0009055

Electron transfer activity

4 of 71

1.43

1.04

0.0039

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009523

Photosystem II

11 of 29

2.26

8.75

1.49e-22

GO:0042651

Thylakoid membrane

11 of 127

1.62

3.94

1.24e-16

GO:0031676

Plasma membrane-derived thylakoid membrane

10 of 108

1.65

3.89

4.66e-15

GO:0009654

Photosystem II oxygen evolving complex

2 of 5

2.28

1.72

0.00056

GO:0009539

Photosystem II reaction center

2 of 6

2.21

1.65

0.00071

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4139

Photosystem II

11 of 18

2.47

10.15

1.57e-23

CL:4141

Photosystem II

7 of 12

2.45

6.31

9.31e-14

CL:4145

Photosystem II cytochrome b559, N-terminal, and Chlorophyll

3 of 5

2.46

2.32

4.34e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00195

Photosynthesis

11 of 73

1.86

5.54

9.98e-19

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009523

Photosystem II

9 of 28

2.19

6.57

2.06e-16

GOCC:0034357

Photosynthetic membrane

10 of 68

1.85

5.02

3.92e-16

GOCC:0030075

Bacterial thylakoid

3 of 24

1.78

1.52

0.00065

GOCC:0030096

Plasma membrane-derived thylakoid photosystem II

2 of 11

1.94

1.08

0.0083

GOCC:0016020

Membrane

11 of 738

0.86

0.95

1.92e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0604

Photosystem II

10 of 18

2.43

9.03

6.70e-21

KW-0793

Thylakoid

10 of 79

1.78

4.64

8.56e-16

KW-0674

Reaction center

2 of 5

2.28

1.37

0.0027

KW-0148

Chlorophyll

2 of 6

2.21

1.36

0.0027

KW-0249

Electron transport

3 of 40

1.56

1.16

0.0027

(more ...)

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