STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HHUB_1573Peptidase M48 family protein. (350 aa)    
Predicted Functional Partners:
HHUB_1572
UPF0104 family protein.
       0.656
HHUB_1575
Peptidase S9 family protein.
 
  
 0.650
HHUB_1574
Uncharacterized protein.
       0.639
grpE
DnaJ/DnaK ATPase stimulator GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several round [...]
  
  
 0.599
HHUB_1780
TRAP-type transport system protein small subunit.
  
     0.527
dnaJ
Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...]
  
 
 0.502
HHUB_1140
Peptidase M24 family protein.
 
  
 0.475
HHUB_2066
Probable coiled coil protein.
  
     0.446
lon
ATP-dependent protease Lon; Belongs to the peptidase S16 family.
   
 
 0.426
dnaK
Hsp70-type molecular chaperone DnaK; Acts as a chaperone.
  
 
 0.415
Your Current Organism:
Halobacterium hubeiense
NCBI taxonomy Id: 1407499
Other names: H. hubeiense, HAMBI 3616, Halobacterium sp. JI20-1, strain JI20-1
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