STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A1J7ILE1Poly [ADP-ribose] polymerase. (698 aa)    
Predicted Functional Partners:
A0A1J7IWW4
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 
 0.910
A0A1J7J0H7
ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase.
   
 
 0.896
A0A1J7IYC9
Zn(2)-C6 fungal-type domain-containing protein.
    
 0.879
A0A1J7J2Z5
Zn(2)-C6 fungal-type domain-containing protein.
    
 0.879
A0A1J7IRU3
Timeless-domain-containing protein.
   
 
 0.820
A0A1J7J696
BRCT domain-containing protein.
    
 0.817
A0A1J7J1N6
XPGI domain-containing protein.
   
 0.815
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
   
 0.815
A0A1J7IY82
Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.
    
 0.811
A0A1J7IAX5
Rad4-domain-containing protein.
    
 0.807
Your Current Organism:
Coniochaeta ligniaria
NCBI taxonomy Id: 1408157
Other names: C. ligniaria NRRL 30616, Coniochaeta ligniaria NRRL 30616
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