node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FEN1 | T310_0541 | A0A0F4Z397 | A0A0F4Z523 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 3'-5' exonuclease/helicase (Wrn). | 0.999 |
FEN1 | T310_0896 | A0A0F4Z397 | A0A0F4Z4K9 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.998 |
FEN1 | T310_2055 | A0A0F4Z397 | A0A0F4Z1C9 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | 0.902 |
FEN1 | T310_2308 | A0A0F4Z397 | A0A0F4Z003 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | RecQ family helicase MusN. | 0.902 |
FEN1 | T310_4907 | A0A0F4Z397 | A0A0F4YTT3 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.572 |
FEN1 | T310_6859 | A0A0F4Z397 | A0A0F4YLU5 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA primase; Belongs to the eukaryotic-type primase small subunit family. | 0.912 |
FEN1 | T310_9541 | A0A0F4Z397 | A0A0F4YFA5 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA replication factor C subunit Rfc5. | 0.945 |
FEN1 | T310_9611 | A0A0F4Z397 | A0A0F4YFT2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.763 |
T310_0541 | FEN1 | A0A0F4Z523 | A0A0F4Z397 | 3'-5' exonuclease/helicase (Wrn). | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.999 |
T310_0541 | T310_0896 | A0A0F4Z523 | A0A0F4Z4K9 | 3'-5' exonuclease/helicase (Wrn). | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.998 |
T310_0541 | T310_2055 | A0A0F4Z523 | A0A0F4Z1C9 | 3'-5' exonuclease/helicase (Wrn). | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | 0.650 |
T310_0541 | T310_2308 | A0A0F4Z523 | A0A0F4Z003 | 3'-5' exonuclease/helicase (Wrn). | RecQ family helicase MusN. | 0.650 |
T310_0541 | T310_4907 | A0A0F4Z523 | A0A0F4YTT3 | 3'-5' exonuclease/helicase (Wrn). | Uncharacterized protein. | 0.589 |
T310_0541 | T310_6859 | A0A0F4Z523 | A0A0F4YLU5 | 3'-5' exonuclease/helicase (Wrn). | DNA primase; Belongs to the eukaryotic-type primase small subunit family. | 0.565 |
T310_0541 | T310_9541 | A0A0F4Z523 | A0A0F4YFA5 | 3'-5' exonuclease/helicase (Wrn). | DNA replication factor C subunit Rfc5. | 0.984 |
T310_0541 | T310_9611 | A0A0F4Z523 | A0A0F4YFT2 | 3'-5' exonuclease/helicase (Wrn). | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.728 |
T310_0698 | T310_4907 | A0A0F4Z588 | A0A0F4YTT3 | Ribonuclease H2 subunit C. | Uncharacterized protein. | 0.922 |
T310_0698 | T310_9611 | A0A0F4Z588 | A0A0F4YFT2 | Ribonuclease H2 subunit C. | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.845 |
T310_0896 | FEN1 | A0A0F4Z4K9 | A0A0F4Z397 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.998 |
T310_0896 | T310_0541 | A0A0F4Z4K9 | A0A0F4Z523 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 3'-5' exonuclease/helicase (Wrn). | 0.998 |