T310_1869 protein (Rasamsonia emersonii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

T310_1869

Fip1 domain-containing protein. (341 aa)

Predicted Functional Partners:

T310_7096

0.998

T310_1333

0.998

T310_5913

0.996

T310_5704

0.995

T310_8221

0.994

T310_5249

0.994

T310_4936

0.994

T310_3619

0.994

T310_6211

0.992

T310_2537

0.992

Your Current Organism:

Rasamsonia emersonii

NCBI taxonomy Id: 1408163
Other names: R. emersonii CBS 393.64, Rasamsonia emersonii CBS 393.64, Rasamsonia emersonii CBS393.64

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T310_1333	T310_1869	A0A0F4Z439	A0A0F4Z0K6	Uncharacterized protein.	Fip1 domain-containing protein.	0.998
T310_1333	T310_2537	A0A0F4Z439	A0A0F4Z050	Uncharacterized protein.	Cleavage and polyadenylation specificity factor subunit 2.	0.998
T310_1333	T310_3619	A0A0F4Z439	A0A0F4YXR5	Uncharacterized protein.	Putative E3 ubiquitin ligase.	0.998
T310_1333	T310_4936	A0A0F4Z439	A0A0F4YSE2	Uncharacterized protein.	Phosphoprotein phosphatase.	0.997
T310_1333	T310_5249	A0A0F4Z439	A0A0F4YS99	Uncharacterized protein.	mRNA cleavage and polyadenylation specificity factor complex subunit (Pta1).	0.997
T310_1333	T310_5704	A0A0F4Z439	A0A0F4YRP3	Uncharacterized protein.	mRNA 3'-end-processing protein rna14.	0.992
T310_1333	T310_5913	A0A0F4Z439	A0A0F4YPA4	Uncharacterized protein.	WD domain, G-beta repeat containing protein.	0.998
T310_1333	T310_6211	A0A0F4Z439	A0A0F4YPM1	Uncharacterized protein.	Uncharacterized protein.	0.995
T310_1333	T310_7096	A0A0F4Z439	A0A0F4YL48	Uncharacterized protein.	WD repeat protein.	0.998
T310_1333	T310_8221	A0A0F4Z439	A0A0F4YHZ1	Uncharacterized protein.	Cleavage and polyadenylation specificity factor subunit A.	0.998
T310_1869	T310_1333	A0A0F4Z0K6	A0A0F4Z439	Fip1 domain-containing protein.	Uncharacterized protein.	0.998
T310_1869	T310_2537	A0A0F4Z0K6	A0A0F4Z050	Fip1 domain-containing protein.	Cleavage and polyadenylation specificity factor subunit 2.	0.992
T310_1869	T310_3619	A0A0F4Z0K6	A0A0F4YXR5	Fip1 domain-containing protein.	Putative E3 ubiquitin ligase.	0.994
T310_1869	T310_4936	A0A0F4Z0K6	A0A0F4YSE2	Fip1 domain-containing protein.	Phosphoprotein phosphatase.	0.994
T310_1869	T310_5249	A0A0F4Z0K6	A0A0F4YS99	Fip1 domain-containing protein.	mRNA cleavage and polyadenylation specificity factor complex subunit (Pta1).	0.994
T310_1869	T310_5704	A0A0F4Z0K6	A0A0F4YRP3	Fip1 domain-containing protein.	mRNA 3'-end-processing protein rna14.	0.995
T310_1869	T310_5913	A0A0F4Z0K6	A0A0F4YPA4	Fip1 domain-containing protein.	WD domain, G-beta repeat containing protein.	0.996
T310_1869	T310_6211	A0A0F4Z0K6	A0A0F4YPM1	Fip1 domain-containing protein.	Uncharacterized protein.	0.992
T310_1869	T310_7096	A0A0F4Z0K6	A0A0F4YL48	Fip1 domain-containing protein.	WD repeat protein.	0.998
T310_1869	T310_8221	A0A0F4Z0K6	A0A0F4YHZ1	Fip1 domain-containing protein.	Cleavage and polyadenylation specificity factor subunit A.	0.994

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.923

expected number of edges:

27

PPI enrichment p-value:

0.98

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140359

ABC-type transporter activity

9 of 45

1.93

4.97

2.96e-14

GO:0042626

ATPase-coupled transmembrane transporter activity

10 of 70

1.79

4.47

8.67e-15

GO:0022857

Transmembrane transporter activity

11 of 443

1.03

1.33

7.09e-10

GO:0005524

ATP binding

10 of 553

0.89

0.96

4.85e-07

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

10 of 1053

0.61

0.51

0.00038

GO:0016020

Membrane

11 of 1493

0.5

0.42

0.00038

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6354

ABC transporter type 1, transmembrane domain, and Peptidase C39 family

7 of 15

2.3

5.42

2.79e-12

CL:6352

ABC transporter type 1, transmembrane domain, and Peptidase C39 family

8 of 29

2.07

5.01

1.07e-12

CL:6255

Mixed, incl. ABC transporter type 1, transmembrane domain, and HlyD family secretion protein

9 of 81

1.68

3.56

4.10e-12

CL:6370

ABC transporter type 1, transmembrane domain

3 of 7

2.26

1.91

0.00023

CL:6356

Mtb iron assimilation by chelation, and Peptidase C39 family

2 of 5

2.23

0.95

0.0176

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02010

ABC transporters

10 of 313

1.14

1.57

2.52e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1222449

Mtb iron assimilation by chelation

8 of 17

2.3

6.83

5.32e-16

MAP-1222499

Latent infection - Other responses of Mtb to phagocytosis

8 of 88

1.59

3.11

3.13e-11

MAP-9635486

Infection with Mycobacterium tuberculosis

8 of 120

1.45

2.55

2.21e-10

MAP-5663205

Infectious disease

8 of 126

1.43

2.48

2.41e-10

MAP-1643685

Disease

8 of 128

1.43

2.46

2.41e-10

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016020

Membrane

10 of 758

0.75

0.69

3.47e-05

GOCC:0005886

Plasma membrane

8 of 538

0.8

0.68

0.00055

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0067

ATP-binding

10 of 423

1.0

1.2

8.18e-08

KW-0472

Membrane

11 of 1036

0.66

0.61

4.33e-06

KW-1133

Transmembrane helix

10 of 1017

0.62

0.54

0.00011

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00664

ABC transporter transmembrane region

8 of 22

2.19

5.69

1.03e-13

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039421

Type 1 protein exporter

9 of 21

2.26

6.73

4.19e-16

IPR036640

ABC transporter type 1, transmembrane domain superfamily

9 of 23

2.22

6.59

4.19e-16

IPR011527

ABC transporter type 1, transmembrane domain

9 of 23

2.22

6.59

4.19e-16

IPR003439

ABC transporter-like, ATP-binding domain

10 of 135

1.5

2.94

2.52e-12

IPR017871

ABC transporter-like, conserved site

9 of 115

1.52

2.83

8.01e-11

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00382

ATPases associated with a variety of cellular activities

10 of 215

1.3

2.11

7.84e-11

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