T310_1728 protein (Rasamsonia emersonii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

T310_1728

Chromosome segregation protein BIR1. (837 aa)

Predicted Functional Partners:

T310_6677

0.976

T310_4782

0.974

T310_9981

0.966

T310_1178

0.951

T310_6254

0.936

T310_6401

0.892

T310_5846

0.892

T310_6350

0.874

T310_0369

0.874

T310_4953

0.853

Your Current Organism:

Rasamsonia emersonii

NCBI taxonomy Id: 1408163
Other names: R. emersonii CBS 393.64, Rasamsonia emersonii CBS 393.64, Rasamsonia emersonii CBS393.64

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T310_0369	T310_1178	A0A0F4Z5Q1	A0A0F4Z2R9	BZIP domain-containing protein.	Ubiquitin--protein ligase; Belongs to the ubiquitin-conjugating enzyme family.	0.964
T310_0369	T310_1728	A0A0F4Z5Q1	A0A0F4Z121	BZIP domain-containing protein.	Chromosome segregation protein BIR1.	0.874
T310_0369	T310_4782	A0A0F4Z5Q1	A0A0F4YTM8	BZIP domain-containing protein.	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.427
T310_0369	T310_4953	A0A0F4Z5Q1	A0A0F4YRT8	BZIP domain-containing protein.	Uncharacterized protein.	0.949
T310_0369	T310_5846	A0A0F4Z5Q1	A0A0F4YQQ0	BZIP domain-containing protein.	Uncharacterized protein.	0.620
T310_0369	T310_6401	A0A0F4Z5Q1	A0A0F4YPS3	BZIP domain-containing protein.	PHD transcription factor (Rum1).	0.620
T310_0369	T310_6677	A0A0F4Z5Q1	A0A0F4YNB6	BZIP domain-containing protein.	Serine/threonine protein kinase (Ark1); Belongs to the protein kinase superfamily.	0.664
T310_0369	T310_9981	A0A0F4Z5Q1	A0A0F4YE25	BZIP domain-containing protein.	Serine/threonine protein kinase.	0.618
T310_1178	T310_0369	A0A0F4Z2R9	A0A0F4Z5Q1	Ubiquitin--protein ligase; Belongs to the ubiquitin-conjugating enzyme family.	BZIP domain-containing protein.	0.964
T310_1178	T310_1728	A0A0F4Z2R9	A0A0F4Z121	Ubiquitin--protein ligase; Belongs to the ubiquitin-conjugating enzyme family.	Chromosome segregation protein BIR1.	0.951
T310_1178	T310_4953	A0A0F4Z2R9	A0A0F4YRT8	Ubiquitin--protein ligase; Belongs to the ubiquitin-conjugating enzyme family.	Uncharacterized protein.	0.972
T310_1178	T310_6350	A0A0F4Z2R9	A0A0F4YN64	Ubiquitin--protein ligase; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin.	0.964
T310_1178	T310_6677	A0A0F4Z2R9	A0A0F4YNB6	Ubiquitin--protein ligase; Belongs to the ubiquitin-conjugating enzyme family.	Serine/threonine protein kinase (Ark1); Belongs to the protein kinase superfamily.	0.747
T310_1178	T310_9981	A0A0F4Z2R9	A0A0F4YE25	Ubiquitin--protein ligase; Belongs to the ubiquitin-conjugating enzyme family.	Serine/threonine protein kinase.	0.714
T310_1728	T310_0369	A0A0F4Z121	A0A0F4Z5Q1	Chromosome segregation protein BIR1.	BZIP domain-containing protein.	0.874
T310_1728	T310_1178	A0A0F4Z121	A0A0F4Z2R9	Chromosome segregation protein BIR1.	Ubiquitin--protein ligase; Belongs to the ubiquitin-conjugating enzyme family.	0.951
T310_1728	T310_4782	A0A0F4Z121	A0A0F4YTM8	Chromosome segregation protein BIR1.	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.974
T310_1728	T310_4953	A0A0F4Z121	A0A0F4YRT8	Chromosome segregation protein BIR1.	Uncharacterized protein.	0.853
T310_1728	T310_5846	A0A0F4Z121	A0A0F4YQQ0	Chromosome segregation protein BIR1.	Uncharacterized protein.	0.892
T310_1728	T310_6254	A0A0F4Z121	A0A0F4YNC4	Chromosome segregation protein BIR1.	INCENP_ARK-bind domain-containing protein.	0.936

page 1 of 4

Network Stats

number of nodes:

5

number of edges:

8

average node degree:

3.2

avg. local clustering coefficient:

0.867

expected number of edges:

4

PPI enrichment p-value:

0.0581

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

4 of 12

1.84

1.58

0.00052

GO:0034654

Nucleobase-containing compound biosynthetic process

5 of 121

0.93

0.5

0.0423

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

4 of 6

2.14

2.25

3.45e-05

GO:0016779

Nucleotidyltransferase activity

5 of 69

1.17

0.99

0.0012

GO:0003677

DNA binding

7 of 182

0.9

0.75

0.00086

GO:0140640

Catalytic activity, acting on a nucleic acid

7 of 196

0.87

0.71

0.0011

GO:1901363

Heterocyclic compound binding

9 of 653

0.45

0.31

0.0306

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000428

DNA-directed RNA polymerase complex

4 of 7

2.07

2.42

1.14e-05

GO:0032991

Protein-containing complex

5 of 191

0.73

0.46

0.0229

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:289

RNA polymerase, and Nucleotide excision repair

6 of 7

2.25

4.17

2.06e-09

CL:97

Ribosome, and Protein export

8 of 105

1.2

1.48

1.07e-06

CL:618

Mixed, incl. WD40-repeat-containing domain superfamily, and ANK repeat

3 of 16

1.59

1.1

0.0044

CL:620

Mixed, incl. WD40-repeat-containing domain superfamily, and ANK repeat

2 of 7

1.77

0.77

0.0315

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

4 of 4

2.31

2.9

2.18e-06

map03420

Nucleotide excision repair

3 of 13

1.68

1.24

0.0024

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9635486

Infection with Mycobacterium tuberculosis

4 of 44

1.27

1.06

0.0014

MAP-5663205

Infectious disease

4 of 47

1.24

1.04

0.0014

MAP-1643685

Disease

4 of 52

1.2

1.0

0.0014

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031931

TORC1 complex

3 of 5

2.09

1.55

0.0010

GOCC:0000428

DNA-directed RNA polymerase complex

4 of 28

1.47

1.25

0.0010

GOCC:0032991

Protein-containing complex

8 of 367

0.65

0.51

0.0019

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

4 of 7

2.07

2.32

1.96e-05

KW-0548

Nucleotidyltransferase

5 of 36

1.46

1.58

6.43e-05

KW-0853

WD repeat

2 of 2

2.31

1.18

0.0064

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036322

WD40-repeat-containing domain superfamily

3 of 4

2.19

1.35

0.0028

IPR015943

WD40/YVTN repeat-like-containing domain superfamily

3 of 4

2.19

1.35

0.0028

IPR001680

WD40 repeat

2 of 2

2.31

0.76

0.0412

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00320

WD40 repeats

2 of 2

2.31

1.08

0.0102

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (18%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About