STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (774 aa)    
Predicted Functional Partners:
KOH44015.1
RNA-dirted RNA polymerase; Pfam: PIF1-like helicase; Pfam: Helix-turn-helix domain; Pfam: HRDC domain; SMART: ATPases associated with a variety of cellular activities; Pfam: Helicase.
  
 0.988
KOH46291.1
ATP-dependent DNA helicase RecQ; Pfam: DEAD/DEAH box helicase; SMART: helicase superfamily c-terminal domain; Pfam: Helicase conserved C-terminal domain; TIGRFAM: recQ_fam: ATP-dependent DNA helicase, RecQ family; SMART: DEAD-like helicases superfamily.
   
 0.974
KOH43844.1
TIGRFAM: recQ_fam: ATP-dependent DNA helicase, RecQ family; SMART:; Pfam: HRDC domain; Pfam: Helicase conserved C-terminal domain; SMART: DEAD-like helicases superfamily; SMART: Helicase and RNase D C-terminal; Pfam: RQC domain; Pfam: DEAD/DEAH box helicase; SMART: helicase superfamily c-terminal domain; TIGRFAM: recQ: ATP-dependent DNA helicase RecQ.
   
 0.974
KOH45470.1
TIGRFAM: pyruv_ox_red: pyruvate:ferredoxin (flavodoxin) oxidoreductase; Pfam: Domain of unknown function; Pfam: 4Fe-4S dicluster domain; Pfam: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; SMART: Domain of unknown function; Pfam: Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg; Pfam: Pyruvate ferredoxin/flavodoxin oxidoreductase.
  
   0.944
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 0.928
recA
Recombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
   
 0.911
sbcD
Hypothetical protein; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
  
 0.877
KOH45406.1
DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.836
KOH44846.1
Hypothetical protein; Pfam: Putative exonuclease SbcCD, C subunit.
  
 0.822
KOH43433.1
Hypothetical protein; Pfam: Putative exonuclease SbcCD, C subunit.
  
 0.822
Your Current Organism:
Sunxiuqinia dokdonensis
NCBI taxonomy Id: 1409788
Other names: CGMCC 1.12676, JCM 19380, KCTC 32503, S. dokdonensis, Sunxiuqinia sp. DH1, strain DH1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.