STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (509 aa)    
Predicted Functional Partners:
guaB
Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 0.999
KOH46430.1
Inosine 5'-monophosphate dehydrogenase; Pfam: IMP dehydrogenase / GMP reductase domain; SMART: Domain in cystathionine beta-synthase and other proteins; Pfam: CBS domain.
 0.997
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 0.968
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
 
 
 0.958
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
  
 0.955
KOH43221.1
Deoxyribonucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
 
 
 0.947
argS
arginyl-tRNA synthetase; TIGRFAM: argS: arginine--tRNA ligase; PRINTS: Arginyl-tRNA synthetase signature; Pfam: Arginyl tRNA synthetase N terminal domain; SMART: Arginyl tRNA synthetase N terminal dom; Pfam: tRNA synthetases class I (R); SMART: DALR anticodon binding domain; Pfam: DALR anticodon binding domain.
   
  
 0.946
hisA
Pfam: Histidine biosynthesis protein; TIGRFAM: TIGR00007: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase.
  
 
 0.932
pyrG
CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
 
 0.925
rplK
50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
   
    0.922
Your Current Organism:
Sunxiuqinia dokdonensis
NCBI taxonomy Id: 1409788
Other names: CGMCC 1.12676, JCM 19380, KCTC 32503, S. dokdonensis, Sunxiuqinia sp. DH1, strain DH1
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