STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Textmining
[Homology]
Score
KOH42804.1Pfam: ACT domain; Pfam: Small subunit of acetolactate synthase; TIGRFAM: acolac_sm: acetolactate synthase, small subunit. (180 aa)    
Predicted Functional Partners:
KOH42805.1
Acetolactate synthase; Pfam: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Pfam: Thiamine pyrophosphate enzyme, central domain; Pfam: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; TIGRFAM: acolac_lg: acetolactate synthase, large subunit, biosynthetic type.
 0.999
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.995
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 0.985
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
 
 
 0.979
KOH44224.1
Aspartokinase; Pfam: Homoserine dehydrogenase; Pfam: ACT domain; TIGRFAM: asp_kinases: aspartate kinase; Pfam: Amino acid kinase family; Pfam: Homoserine dehydrogenase, NAD binding domain.
 
 
 0.960
KOH46154.1
Hypothetical protein; Pfam: Pyridoxal-phosphate dependent enzyme.
  
 
 0.958
KOH44668.1
2-isopropylmalate synthase; Pfam: LeuA allosteric (dimerisation) domain; Pfam: HMGL-like; SMART: LeuA allosteric (dimerisation) domain; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.958
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.957
ilvD-2
TIGRFAM: ilvD: dihydroxy-acid dehydratase; Pfam: Dehydratase family; Belongs to the IlvD/Edd family.
 
 0.957
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.952
Your Current Organism:
Sunxiuqinia dokdonensis
NCBI taxonomy Id: 1409788
Other names: CGMCC 1.12676, JCM 19380, KCTC 32503, S. dokdonensis, Sunxiuqinia sp. DH1, strain DH1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.