node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aceB | acs | GCA_001590885_03745 | GCA_001590885_04107 | Unannotated protein; Belongs to the malate synthase family. | Unannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.960 |
aceB | adhE | GCA_001590885_03745 | GCA_001590885_00018 | Unannotated protein; Belongs to the malate synthase family. | Unannotated protein; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 0.915 |
aceB | prpB | GCA_001590885_03745 | GCA_001590885_02663 | Unannotated protein; Belongs to the malate synthase family. | Unannotated protein; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. | 0.940 |
aceB | prpC | GCA_001590885_03745 | GCA_001590885_02662 | Unannotated protein; Belongs to the malate synthase family. | Unannotated protein; Belongs to the citrate synthase family. | 0.571 |
aceB | sucC | GCA_001590885_03745 | GCA_001590885_04309 | Unannotated protein; Belongs to the malate synthase family. | Unannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.838 |
aceB | sucD | GCA_001590885_03745 | GCA_001590885_04310 | Unannotated protein; Belongs to the malate synthase family. | Unannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.848 |
aceB | thlA | GCA_001590885_03745 | GCA_001590885_00359 | Unannotated protein; Belongs to the malate synthase family. | Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. | 0.925 |
acnB | frdA | GCA_001590885_03360 | GCA_001590885_04685 | Unannotated protein; Belongs to the aconitase/IPM isomerase family. | Unannotated protein. | 0.582 |
acnB | prpB | GCA_001590885_03360 | GCA_001590885_02663 | Unannotated protein; Belongs to the aconitase/IPM isomerase family. | Unannotated protein; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. | 0.932 |
acnB | prpC | GCA_001590885_03360 | GCA_001590885_02662 | Unannotated protein; Belongs to the aconitase/IPM isomerase family. | Unannotated protein; Belongs to the citrate synthase family. | 0.745 |
acnB | prpD | GCA_001590885_03360 | GCA_001590885_02661 | Unannotated protein; Belongs to the aconitase/IPM isomerase family. | Unannotated protein. | 0.918 |
acnB | sucC | GCA_001590885_03360 | GCA_001590885_04309 | Unannotated protein; Belongs to the aconitase/IPM isomerase family. | Unannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.808 |
acnB | sucD | GCA_001590885_03360 | GCA_001590885_04310 | Unannotated protein; Belongs to the aconitase/IPM isomerase family. | Unannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.642 |
acs | aceB | GCA_001590885_04107 | GCA_001590885_03745 | Unannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Unannotated protein; Belongs to the malate synthase family. | 0.960 |
acs | adhE | GCA_001590885_04107 | GCA_001590885_00018 | Unannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Unannotated protein; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 0.955 |
acs | frdA | GCA_001590885_04107 | GCA_001590885_04685 | Unannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Unannotated protein. | 0.527 |
acs | prpB | GCA_001590885_04107 | GCA_001590885_02663 | Unannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Unannotated protein; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. | 0.914 |
acs | prpC | GCA_001590885_04107 | GCA_001590885_02662 | Unannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Unannotated protein; Belongs to the citrate synthase family. | 0.971 |
acs | prpD | GCA_001590885_04107 | GCA_001590885_02661 | Unannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Unannotated protein. | 0.442 |
acs | sucC | GCA_001590885_04107 | GCA_001590885_04309 | Unannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Unannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.884 |