STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yitJBifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (327 aa)    
Predicted Functional Partners:
metH_2
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
 
 
 0.991
ETN92464.1
Hypothetical protein; Methylene-tetrahydrofolate reductase C terminal.
     0.983
acsE
5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase.
 
 
 0.961
ETN92461.1
Methylamine methyltransferase corrinoid protein reductive activase.
 
     0.907
metH_1
Methionine synthase.
 
 
  0.890
ETN92465.1
Hypothetical protein.
 
    0.760
gcvT_2
Aminomethyltransferase; Belongs to the GcvT family.
 
 
 0.731
metK
S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.731
ETN92468.1
Trimethylamine:corrinoid methyltransferase; Belongs to the trimethylamine methyltransferase family.
 
    0.725
gcvP
Glycine dehydrogenase [decarboxylating]; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
    
 0.717
Your Current Organism:
Gammaproteobacteria bacterium MOLA455
NCBI taxonomy Id: 1411685
Other names: G. bacterium MOLA455
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.