node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CQD08442.1 | CQD08473.1 | BN1232_01516 | BN1232_01521 | Superfamily protein I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily. | ATP-dependent DNA helicase II uvrD2. | 0.999 |
CQD08442.1 | CQD16073.1 | BN1232_01516 | BN1232_03462 | Superfamily protein I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily. | Exonuclease, DNA polymerase III subunit epsilon family. | 0.965 |
CQD08442.1 | CQD20273.1 | BN1232_01516 | BN1232_04869 | Superfamily protein I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily. | ATP-dependent DNA helicase PcrA. | 0.960 |
CQD08442.1 | dnaN | BN1232_01516 | BN1232_00177 | Superfamily protein I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.872 |
CQD08442.1 | recA | BN1232_01516 | BN1232_02124 | Superfamily protein I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.963 |
CQD08442.1 | rpoB | BN1232_01516 | BN1232_01094 | Superfamily protein I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.758 |
CQD08442.1 | topA | BN1232_01516 | BN1232_05404 | Superfamily protein I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.836 |
CQD08442.1 | uvrA | BN1232_01516 | BN1232_02660 | Superfamily protein I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily. | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.548 |
CQD08442.1 | uvrB | BN1232_01516 | BN1232_02654 | Superfamily protein I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily. | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.850 |
CQD08442.1 | uvrC | BN1232_01516 | BN1232_02444 | Superfamily protein I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily. | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.771 |
CQD08473.1 | CQD08442.1 | BN1232_01521 | BN1232_01516 | ATP-dependent DNA helicase II uvrD2. | Superfamily protein I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily. | 0.999 |
CQD08473.1 | CQD16073.1 | BN1232_01521 | BN1232_03462 | ATP-dependent DNA helicase II uvrD2. | Exonuclease, DNA polymerase III subunit epsilon family. | 0.976 |
CQD08473.1 | CQD20273.1 | BN1232_01521 | BN1232_04869 | ATP-dependent DNA helicase II uvrD2. | ATP-dependent DNA helicase PcrA. | 0.995 |
CQD08473.1 | dnaN | BN1232_01521 | BN1232_00177 | ATP-dependent DNA helicase II uvrD2. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.998 |
CQD08473.1 | recA | BN1232_01521 | BN1232_02124 | ATP-dependent DNA helicase II uvrD2. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.999 |
CQD08473.1 | rpoB | BN1232_01521 | BN1232_01094 | ATP-dependent DNA helicase II uvrD2. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.981 |
CQD08473.1 | topA | BN1232_01521 | BN1232_05404 | ATP-dependent DNA helicase II uvrD2. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.999 |
CQD08473.1 | uvrA | BN1232_01521 | BN1232_02660 | ATP-dependent DNA helicase II uvrD2. | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.788 |
CQD08473.1 | uvrB | BN1232_01521 | BN1232_02654 | ATP-dependent DNA helicase II uvrD2. | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.919 |
CQD08473.1 | uvrC | BN1232_01521 | BN1232_02444 | ATP-dependent DNA helicase II uvrD2. | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.700 |