STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spoVAFStage V sporulation protein AF; Derived by automated computational analysis using gene prediction method: Protein Homology. (482 aa)    
Predicted Functional Partners:
spoIIAA
Anti-sigma F factor antagonist; In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma f from inhibition; Belongs to the anti-sigma-factor antagonist family.
 
   
 0.948
spoIIAB
Anti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
 
   
 0.947
sigF_2
RNA polymerase sigma-F factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
     0.947
spoVAD
Stage V sporulation protein AD; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.877
spoVAC_2
Stage V sporulation protein AC; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.866
spoVA2
Stage V sporulation protein AE; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.847
gpr
GPR endopeptidase; Initiates the rapid degradation of small, acid-soluble proteins during spore germination; Belongs to the peptidase A25 family.
  
    0.802
sigK
RNA polymerase subunit sigma-70; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family.
 
    0.792
yabP
Sporulation protein YabP; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   
 0.782
spoIIID
Stage III sporulation protein D; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   
 0.782
Your Current Organism:
Lysinibacillus sphaericus
NCBI taxonomy Id: 1421
Other names: ATCC 14577, B-23268, BCRC 12825, Bacillus sp. G10(2009), Bacillus sphaericus, CCM 2120, CCRC 12825, CCRC:12825, CCUG 7428, CIP 65.30, DSM 28, IAM 13420, JCM 2502, KCTC 3346, L. sphaericus, LMG 7134, LMG:7134, NBRC 15095, NCCB 75018, NCIMB 9370, NCTC 10338, NRRL B-23268, VKM B-509
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