STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRL86581.1Response regulator. (371 aa)    
Predicted Functional Partners:
KRL86582.1
Hypothetical protein.
 
 
 0.979
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
    
  0.912
KRL83964.1
Pyruvate kinase; Belongs to the pyruvate kinase family.
    
  0.907
guaB
Inosine 5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
  0.898
KRL86578.1
Glycosyltransferase.
 
 
 0.718
leuS
leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
   0.646
KRL83593.1
Two-component response regulator.
  
 
 0.621
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
    
  0.608
KRL87109.1
Nucleoside diphosphate kinase; Belongs to the NDK family.
    
  0.607
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
    
  0.590
Your Current Organism:
Lactobacillus apodemi
NCBI taxonomy Id: 1423724
Other names: L. apodemi DSM 16634 = JCM 16172, Lactobacillus apodemi DSM 16634, Lactobacillus apodemi DSM 16634 = JCM 16172, Lactobacillus apodemi JCM 16172, Lactobacillus apodemi JCM 16172 = DSM 16634
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